Korean J Dermatol.
1993 Dec;31(6):884-889.
In vitro senstivity of sporothrix schenckii against antifungal agents
Abstract
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BACKGROUND: Despite concern about treatment of sporotrichosis, little is known about the sensitivity of S. schenckii against antifungal agents.
OBJECTIVE
The purpose of the study was to investigate minimal irihibitory concentration(MIC) of antifungal agents against S.chenckii. METHOD: The tested strains were seven in number. The tested antifngal agents were ketoconazole, itraconazole, amphotericin B, and potassium iodide. A various concentration of drugs were mixed into fluid media containing 50% ethanol, dimethyl sulfoxide, and distilled water. The inoculum consisted of 3mm block containing hyphae and spores.
RESULTS
MIC ranges of ket.oconazole, itraconazole, amphotericin B, and potassium iodide were 0.39- 25pg/ml, 0.78-25pg/ml, 0.78-25pg/ml, and 75-550pg/ml, respectively.
CONCLUSION
We find that ketoconazole is the most active drug against S. schenckii.
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