Korean J Dermatol.  1998 Dec;36(6):1074-1077.

A Case of Lupus Erythematosus Panniculitis with Infiltration of Atypical Lymphocytes

• Park SJ
• Han KS
• Lee HG
• Kim JM

Abstract

Lupus erythematosus panniculitis is a rare variant of lupus erythematosus primarily involving a panniculus with or without discoid lupus erythematosus in the overlying skin. A 34-year-old woman showed multiple, variable-sized, indurated subcutaneous nodules on both her upper arms and axillae. A Histopathological examination revealed lobular panniculitis with infiltration of several hyperchromatic atypical large lymphocytes. The infiltrated cells were positively stained with LCA, UCHL-1, CD4, CD8, but not with CD20 and CD68. A T cell receptor -chain gene and immunoglobulin heavy chain gene rearrangement study showed no monoclonality. The result of an ANA test was positive at 1: 40 in a homogeneous pattern. Skin lesions were improved by combined therapy with daily hydroxychloroquine 400mg and prednisolone 10mg in a week and after 6weeks, resolved with atrophic depressed scars. After 4 months, she complained of symptoms of the Raynaud phenomenon and was managed by nifedipine. There has been no recurrence during follow-up for 7 months.

Keyword

Lupus erythematosus panniculitis; Atypical lymphocytes

MeSH Terms

Adult
Arm
Axilla
Cicatrix
Female
Follow-Up Studies
Gene Rearrangement
Humans
Hydroxychloroquine
Immunoglobulin Heavy Chains
Lupus Erythematosus, Discoid
Lymphocytes*
Nifedipine
Panniculitis
Panniculitis, Lupus Erythematosus*
Prednisolone
Raynaud Disease
Receptors, Antigen, T-Cell
Recurrence
Skin
Hydroxychloroquine
Immunoglobulin Heavy Chains
Nifedipine
Prednisolone
Receptors, Antigen, T-Cell