Korean Circ J.  1993 Jun;23(3):454-460. 10.4070/kcj.1993.23.3.454.

Effect of terazosin on blood pressure and serum lipids in nild to moderate hypertension

• Kim JP
• Kang IK
• Shim SC
• Lee OC
• Kim KS
• Kim JH
• Im HK
• Lee BH
• Lee CK

• KMID: 2229237
• DOI: http://doi.org/10.4070/kcj.1993.23.3.454

Abstract

BACKGROUND
We evaluated the antihypertensive effect, safety and effect on serum lipids of terazosin, second generation alpha1-blocker. METHODS: Terazosin 1-4mg was adminstered once daily in 20 patients for 12 weeks with dose titration every 2 weeks. RESULTS: 1) The systolic and diastolic blood pressure were decreased from 170.0+/-13.0/104.0+/-6.0mmHg to 144.0+/-13.3/88.0+/-5.6mmHg(p<0.01), but the heart rate and body weight were independant of terazosin administration. 2) Total cholesterol was decreased significantly from 209.9+/-33.5mg/dL to 194.6+/-30.1mg/dL after 12 weeks treatment(p<0.05), triglyceride was decreased significantly from 185.4+/-37.0mg/dL to 168.9+/-35.0mg/dL(p<0.05). and LDL-cholesterol was decreased significantly from 134.5+/-31.9mg/dL to 122.7+/-29.9mg/dL(p<0.05), but HDL-cholesterol was increased significantly from 37.8+/-5.6mg/dL to 40.6+/-5.5mg/dL(p<0.05). 3) The adverse effects of terazosin were dizziness in 2, headache in 2, asthenia in 1, peripheral edema in 1 and skin rash in 1 patient, but were not troublesome enough to stop medication. CONCLUSIONS: Terazosin 1-4mg once daily regimen was effective and safe as an antihypertensive agent, and moreover terazosin has favorable effects on serum lipids.

MeSH Terms

Asthenia
Blood Pressure*
Body Weight
Cholesterol
Dizziness
Edema
Exanthema
Headache
Heart Rate
Humans
Hypertension*
Triglycerides
Cholesterol