Korean Circ J.  2002 Sep;32(9):773-780. 10.4070/kcj.2002.32.9.773.

The Long-Term Clinical Effects of Heparin-Coated Coronary Stent

• Park HW
• Jeong MH
• Park OY
• Kim IS
• Choi MJ
• Lee SH
• Hong YJ
• Kim W
• Kim JH
• Park WS
• Rhew JY
• Ahn YK
• Cho JG
• Cho DL
• Park JC
• Kang JC

• KMID: 2227255
• DOI: http://doi.org/10.4070/kcj.2002.32.9.773

Abstract

BACKGROUND AND OBJECTIVES: A heparin-coated stent has been reported to be effective in the prevention of restenosis in a porcine model. The aim of this study was to compare the long term effects of heparin-coated and bare stents in patients who underwent percutaneous coronary intervention (PCI), with regard to the clinical and angiographic outcomes.
SUBJECTS AND METHODS
Thirty patients who underwent PCI at Chonnam National University Hospital between July 1999 and December 2000 were randomly assigned into two groups; Group I had control bare stents (n=15, 15 lesions, 59+/-12 years, 13 males) and Group II heparin coated stents (n=15, 15 lesions, 59+/-11 years, 14 males). Six months following stenting, follow-up coronary angiograms were performed in 24 (80%) patients. The average follow-up period was 22+/-6 months.
RESULTS
The initial clinical and angiographic characteristics were no different between the two groups. The reference diameters (Group I; 2.84+/-0.57 mm, II; 3.34+/-0.57 mm), minimal luminal (Group I; 2.37+/-0.60 mm, II; 2.60+/-0.59 mm) and diameter stenosis (Group I; 16.8+/-8.8%, II; 22.6+/-8.6%) following stenting, were no different between the two groups. Subacute stent thrombosis was observed in 1 patient (6.7%) of Group I. On follow-up coronary angiograms, the reference (group I; 2.46+/-0.34 mm, group II; 2.70+/-0.43 mm), minimal luminal diameters (group I; 1.47+/-0.59 mm, group II; 1.64+/-0.80 mm) and diameter stenosis (group I; 39.4+/-25.1%, group II; 40.8+/-26.1%) diameters were also no different, and restenosis was observed in 3 (25%) patients of each group. One cardiac death and 3 target vessel revascularizations were observed in each group during follow-up.
CONCLUSION
The heparin-coated coronary stents were not effective in the prevention of coronary stent restenosis.

Keyword

Coronary diseases; Heparin; Stents; Restenosis

MeSH Terms

Constriction, Pathologic
Coronary Disease
Death
Follow-Up Studies
Heparin
Humans
Jeollanam-do
Percutaneous Coronary Intervention
Phenobarbital
Stents*
Thrombosis
Heparin
Phenobarbital