Korean Circ J.  2004 Nov;34(11):1063-1069. 10.4070/kcj.2004.34.11.1063.

The Long-Term Clinical Results of a Platelet Glycoprotein IIb/IIIa Receptor Blocker (Abciximab : ReoPro(R)) Coated Stent in Patients with Acute Myocardial Infarction

• Kim W
• Jeong MH
• Hong YJ
• Park HW
• Lee GM
• Jeong SY
• Kim IS
• Kim KH
• Yoon KH
• Kang DK
• Hong SN
• Lim SY
• Lee SH
• Lee YS
• Kim JH
• Ahn YK
• Cho JG
• Park JC
• Kim H
• Cho DL
• Kang JC

• KMID: 2227179
• DOI: http://doi.org/10.4070/kcj.2004.34.11.1063

Abstract

BACKGROUND AND OBJECTIVES
The inhibition of coronary restenosis with an Abciximab (ReoPro(R))-coated stent has previously been reported by us. This study investigated the clinical outcomes of patients with acute myocardial infarction (AMI) treated with ReoPro-coated stents.
SUBJECTS AND METHOD
A prospective randomized trial was conducted to compare two types of stent for the revascularization in 63 patients [Group I (ReoPro(r)-coated stent):n=32, 53.7+/-11.8 years, 27 male, and Group II (control stent):n=31, 55.4+/-12.1 years, 27 male] with AMI. The primary effective end points were major adverse coronary events (MACE):cardiac death, acute myocardial infarction, target lesion revascularization (TLR), in-stent restenosis and late lumen loss at the 1 year clinical and angiographic follow-ups.
RESULTS
Baseline clinical characteristics and diameters of stenosis and the minimal luminal diameters were no different between the two groups. There was one myocardial infarction and revascularization during the hospital stay in group II. Follow-up coronary angiograms were performed in 71.9 (23/32) and 77.4% (24/31) of groups I and II, respectively. The diameter of stenosis and late loss were significantly lower in group I than group II (19.4+/-5.1 vs. 34.8+/-5.9%, p=0.013;and 0.39+/-0.26 vs. 0.89+/-0.45 mm;p=0.008, respectively). However, the restenosis rates were no different between the two groups (21.7 vs. 37.5%, p=0.341). One year clinical follow-ups were possible in 98.4% (62/63), and there were two AMI found in group II, but none in group I. The TLR rates and total MACE of group I were relatively lower compared with group II [12.9 (4/31) vs. 29.0% (9/31);p=0.122 and 12.9 (4/31) vs. 35.5% (11/31), p=0.038, respectively].
CONCLUSION
The ReoPro(R)-coated stent was safe, with no stent thrombosis, and effective in patients with AMI.

Keyword

Platelets; Receptor; Coronary artery disease; Coronary restenosis; Stents

MeSH Terms

Blood Platelets*
Constriction, Pathologic
Coronary Artery Disease
Coronary Restenosis
Follow-Up Studies
Glycoproteins*
Humans
Length of Stay
Male
Myocardial Infarction*
Phenobarbital
Prospective Studies
Stents*
Thrombosis
Glycoproteins
Phenobarbital