Korean J Intern Med.  2004 Dec;19(4):220-229.

The Long-term Clinical Results of a Platelet Glycoprotein IIb/IIIa Receptor Blocker (Abciximab: ReoPro (R) ) Coated Stent in Patients with Coronary Artery Disease

• Kim W
• Jeong MH
• Hong YJ
• Lee SH
• Park WS
• Kim JH
• Kim IS
• Choi MJ
• Ahn YK
• Cho JG
• Park JC
• Cho DL
• Kim H
• Kang JC

Abstract

BACKGROUND
Previously, the inhibition of coronary restenosis with Abciximab (ReoPro (R) ) -coated stent in a porcine model was reported. ReoPro (R) inhibits platelet aggregation, the proliferation of vascular smooth muscle cells and the inflammatory reaction. METHODS: A prospective randomized trial was performed to compare two types of stent for revascularization in the native coronary artery. The primary effective end points were major adverse coronary events (MACE) : cardiac death, acute myocardial infarction, target vessel revascularization (TVR) and restenosis at the 6-month clinical and angiographic follow-ups. RESULTS: One hundred and fifty-five patients were enrolled between August 2001 and June 2003. The mean ages (56.0 +/- 10.0 vs. 56.9 +/- 10.8 years), baseline diameter of stenosis and minimal luminal diameter were no different between the two groups. There was one myocardial infarction and revascularization during the hospital stay in control stent group. During the clinical follow-up there were two myocardial infarctions in control group. Follow-up coronary angiograms were performed in 62.3% (48/77) and 65.4% (51/78) of the coated and control groups, respectively. The diameter of stenosis and late loss were significantly less in the ReoPro (R) -coated stent group compared with the controls (16.4 +/- 5.8% vs. 34.3 +/- 6.1%, p=0.009; and 0.33 +/- 0.28 mm vs. 0.88 +/- 0.41 mm; p=0.002). The restenosis and TVR rates of the ReoPro (R) -coated stent were relatively lower compared with the control stent [14.6% (7/48) vs. 29.4% (15/51), p=0.062; and 9.2% (7/76) vs. 14.7% (11/75) ; p=0.327]. CONCLUSION: A ReoPro (R) -coated stent is safe, and may be effective in the prevention of coronary restenosis.

Keyword

Stents; Coronary Artery Diseases; Platelets; Restenosis

MeSH Terms

Antibodies, Monoclonal/pharmacokinetics/*therapeutic use
Coated Materials, Biocompatible/pharmacokinetics/*therapeutic use
Coronary Arteriosclerosis/*surgery
Coronary Restenosis/epidemiology/prevention & control
Female
Humans
Immunoglobulins, Fab/*therapeutic use
Korea/epidemiology
Male
Middle Aged
Platelet Aggregation Inhibitors/pharmacokinetics/*therapeutic use
Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors
Prospective Studies
Research Support, Non-U.S. Gov't
*Stents