Korean Circ J.  2005 May;35(5):369-374. 10.4070/kcj.2005.35.5.369.

The Relationship between Hemoglobin A1c and Major Adverse Cardiac Events in Nondiabetic Acute Myocardial Infarction Patients Underwent Primary Percutaneous Coronary Intervention

• Lee YS
• Jeong MH
• Kim KH
• Kang DG
• Yun KH
• Lee SH
• Lim SY
• Hong SN
• Park HW
• Hong YJ
• Kim JH
• Kim W
• Ahn YK
• Cho JG
• Park JC
• Kang JC

• KMID: 2227142
• DOI: http://doi.org/10.4070/kcj.2005.35.5.369

Abstract

BACKGROUND AND OBJECTIVES
Hyperglycemia on hospital admission is a known important risk factor in patients with acute myocardial infarction. The purpose of this study was to investigate the relation between the level of hemoglobin A1c (HbA1c) and major adverse cardiac events (MACE) in non-diabetic acute myocardial infarction patients who underwent primary percutaneous coronary intervention (PCI).
SUBJECTS AND METHODS
Of the 105 acute myocardial infarction patients who underwent primary PCI between January 2002 and December 2002, 68 non diabetic patients were analyzed. The patients were divided into two groups: group I (n=46, 58.7+/-12.5 years, 37 male) with low levels of HbA1c (<6%) and group II (n=22, 64.6+/-13.1 years, 18 male) with elevated levels of HbA1c (6% to 7%). MACE was observed during the six-month clinical follow-up.
RESULTS
There were no differences in the risk factors for atherosclerosis and angiographic characteristics between the two groups. Group II had a significantly higher rate of MACE (13% vs. 36%, p=0.026) compared to Group I. Logistic regression analysis disclosed that an elevated level of HbA1c, between 6 and 7%, was a significant independent predictor of MACE.
CONCLUSION
An elevated level of HbA1c is a significant prognostic factor in non-diabetic acute myocardial infarction patients after primary PCI.

Keyword

Myocardial infarction; Diabetes mellitus; Prognosis; Angioplasty

MeSH Terms

Angioplasty
Atherosclerosis
Diabetes Mellitus
Follow-Up Studies
Humans
Hyperglycemia
Logistic Models
Myocardial Infarction*
Percutaneous Coronary Intervention*
Prognosis
Risk Factors