Korean Circ J.  2007 Mar;37(3):113-118. 10.4070/kcj.2007.37.3.113.

Predictive Factors for the Recovery of Left Ventricular Dysfunction in Patients with Acute Myocardial Infarction

• Lim SC
• Rhee JA
• Jeong MH
• Choi JS
• Shin ES
• Kim KH
• Kim JH
• Moon JY
• Hong YJ
• Ahn YK
• Cho JG
• Park JC
• Kang JC

• KMID: 2227082
• DOI: http://doi.org/10.4070/kcj.2007.37.3.113

Abstract

BACKGROUND AND OBJECTIVES: The left ventricular ejection fraction (LVEF) is known to be a significant prognostic factor for patients with acute myocardial infarction (AMI). The aim of this study was to investigate clinical or therapeutic factors associated with the recovery of a low LVEF for patients with AMI.
SUBJECTS AND METHODS
From January to December 2004, we enrolled 89 patients (mean age: 62.5+/-10.6 years, 43 males and 26 females) with AMI and who had a LVEF less than 50%. Forty five patients whose LVEF improved more than 10% were classified as group I (mean age: 62.4+/-10.4 years, 34 males and 11 females) and 44 patients whose LVEF was not changed or decreased were classified as group II (mean age: 62.3+/-10.9 years, 29 males and 15 females). The clinical variables, including risk factors and the pain-to-door time, the biochemical markers of myocardial injury, the coronary angiographic findings and the treatment-related variables, were compared between the two groups.
RESULTS
The cardiovascular risk factors were not different between the groups. The location of infarction, the success rate of percutaneous coronary intervention and the coronary angiographic lesion morphologies were not different between the groups. However, the pain-to-door time was significantly shorter in group I than in group II (6.0+/-9.5 vs 22.4+/-7.5 hours, respectively, p=0.046). Improved control of risk factors was not associated with the recovery of LV function. The use of beta-blocker, statin, anti-platelet agents, vasodilators and diuretics were not different between the groups. However, the use of angiotensin converting enzyme inhibitor (ACEI) was more common in group I than group II (79.3% vs 47.4%, respectively, p=0.03).
CONCLUSION
A shorter pain-to-door time and the use of ACEI were significant predictors of the recovery of LV dysfunction for patients with AMI.

Keyword

Myocardial infarction; Heart failure, congestive; Angiotensin

MeSH Terms

Angiotensins
Biomarkers
Diuretics
Heart Failure
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Infarction
Male
Myocardial Infarction*
Peptidyl-Dipeptidase A
Percutaneous Coronary Intervention
Risk Factors
Stroke Volume
Vasodilator Agents
Ventricular Dysfunction, Left*
Angiotensins
Diuretics
Peptidyl-Dipeptidase A
Vasodilator Agents

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