Korean J Clin Pathol.
2001 Aug;21(4):269-273.
Type III hyperlipoproteinemia associated with generalized tuberoeruptive xanthomas
- Affiliations
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- 1Department of Clinical Pathology, Chonbuk National University Medical School, Chonju, Korea.
- 2Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, Korea.
Abstract
- A 61-year-old female patient presented with the type III hyperlipoproteinemia (HLP) in association with generalized eruptive and tuberous xanthomas. She had hypercholesterolemia and hypertriglyceridemia, and extensive coronary atherosclerosis. Further studies revealed a positive standing plasma test, abnormal beta-very low density lipoprotein (VLDL) on lipoprotein electrophoresis, markedly elevated very low density lipoprotein-cholesterol (VLDL-C) to plasma triglycerides (TG) ratio (0.86) and homozygosity for apolipoprotein E2. After about one year of therapy with lipid-lowering agents and diet restriction, a significant reduction of serum cholesterol and TG was observed and the yellowish orange discolorations of palmar creases disappeared from her palms.