Korean J Clin Pathol.  2001 Aug;21(4):269-273.

Type III hyperlipoproteinemia associated with generalized tuberoeruptive xanthomas

Affiliations
  • 1Department of Clinical Pathology, Chonbuk National University Medical School, Chonju, Korea.
  • 2Research Institute of Clinical Medicine, Chonbuk National University Medical School, Chonju, Korea.

Abstract

A 61-year-old female patient presented with the type III hyperlipoproteinemia (HLP) in association with generalized eruptive and tuberous xanthomas. She had hypercholesterolemia and hypertriglyceridemia, and extensive coronary atherosclerosis. Further studies revealed a positive standing plasma test, abnormal beta-very low density lipoprotein (VLDL) on lipoprotein electrophoresis, markedly elevated very low density lipoprotein-cholesterol (VLDL-C) to plasma triglycerides (TG) ratio (0.86) and homozygosity for apolipoprotein E2. After about one year of therapy with lipid-lowering agents and diet restriction, a significant reduction of serum cholesterol and TG was observed and the yellowish orange discolorations of palmar creases disappeared from her palms.

Keyword

Type III hyperlipoproteinemia; Apolipoprotein E; apo 2/2; Xanthoma

MeSH Terms

Apolipoprotein E2
Cholesterol
Citrus sinensis
Coronary Artery Disease
Diet
Electrophoresis
Female
Humans
Hypercholesterolemia
Hyperlipoproteinemia Type III*
Hypertriglyceridemia
Lipoproteins
Middle Aged
Plasma
Triglycerides
Xanthomatosis*
Apolipoprotein E2
Cholesterol
Lipoproteins
Triglycerides
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