1. Blair SN, Morris JN. Healthy hearts and the universal benefits of being physically active: physical activity and health. Ann Epidemiol. 2009. 19:253–256.
2. Siscovick DS, Weiss NS, Fletcher RH, Lasky T. The incidence of primary cardiac arrest during vigorous exercise. N Engl J Med. 1984. 311:874–877.
3. Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO. Sudden deaths in young competitive athletes: analysis of 1866 deaths in the United States, 1980-2006. Circulation. 2009. 119:1085–1092.
4. Wever EF, Robles de Medina EO. Sudden death in patients without structural heart disease. J Am Coll Cardiol. 2004. 43:1137–1144.
5. Sofi F, Capalbo A, Cesari F, Abbate R, Gensini GF. Physical activity during leisure time and primary prevention of coronary heart disease: an updated meta-analysis of cohort studies. Eur J Cardiovasc Prev Rehabil. 2008. 15:247–257.
6. Sesso HD, Paffenbarger RS Jr, Lee IM. Physical activity and coronary heart disease in men: the Harvard Alumni Health Study. Circulation. 2000. 102:975–980.
7. Wendel-Vos GC, Schuit AJ, Feskens EJ, et al. Physical activity and stroke: a meta-analysis of observational data. Int J Epidemiol. 2004. 33:787–798.
8. Lee CD, Folsom AR, Blair SN. Physical activity and stroke risk: a meta-analysis. Stroke. 2003. 34:2475–2481.
9. Lee IM, Paffenbarger RS Jr. Physical activity and stroke incidence: the Harvard Alumni Health Study. Stroke. 1998. 29:2049–2054.
10. Lee IM, Hennekens CH, Berger K, Buring JE, Manson JE. Exercise and risk of stroke in male physicians. Stroke. 1999. 30:1–6.
11. Lee IM. Physical activity and cancer prevention: data from epidemiologic studies. Med Sci Sports Exerc. 2003. 35:1823–1827.
12. Lee IM, Cook NR, Rexrode KM, Buring JE. Lifetime physical activity and risk of breast cancer. Br J Cancer. 2001. 85:962–965.
13. Oguma Y, Sesso HD, Paffenbarger RS Jr, Lee IM. Physical activity and all cause mortality in women: a review of the evidence. Br J Sports Med. 2002. 36:162–172.
14. Lee IM, Hsieh CC, Paffenbarger RS Jr. Exercise intensity and longevity in men. The Harvard Alumni Health Study. JAMA. 1995. 273:1179–1184.
15. Lee IM, Skerrett PJ. Physical activity and all-cause mortality: what is the dose-response relation? Med Sci Sports Exerc. 2001. 33:6 Suppl. S459–S471.
16. Vogel T, Brechat PH, Leprětre PM, Kaltenbach G, Berthel M, Lonsdorfer J. Health benefits of physical activity in older patients: a review. Int J Clin Pract. 2009. 63:303–320.
17. Blair SN, Morris JN. Healthy hearts and the universal benefits of being physically active: physical activity and health. Ann Epidemiol. 2009. 19:253–256.
18. Pate RR, Pratt M, Blair SN, et al. Physical activity and public health: a recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA. 1995. 273:402–407.
19. Lee IM. Dose-response relation between physical activity and fitness: even a little is good; more is better. JAMA. 2007. 297:2137–2139.
20. Manson JE, Greenland P, LaCroix AZ, et al. Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med. 2002. 347:716–725.
21. Lee IM, Sesso HD, Oguma Y, et al. The "weekend warrior" and risk of mortality. Am J Epidemiol. 2004. 160:636–641.
22. Lee IM. Physical activity in women: how much is good enough? JAMA. 2003. 290:1377–1379.
23. Church TS, Earnest CP, Skinner JS, Blair SN. Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial. JAMA. 2007. 297:2081–2091.
24. American College of Sports Medicine position statement on the recommended quantity and quality of exercise for developing and maintaining fitness in healthy adults. Med Sci Sports. 1978. 10:vii–x.
25. Haskell WL, Lee IM, Pate RR, et al. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation. 2007. 116:1081–1093.
26. Lee IM, Sesso HD, Paffenbarger RS Jr. Physical activity and coronary heart disease risk in men: does the duration of exercise episodes predict risk? Circulation. 2000. 102:981–986.
27. Thompson PD, Franklin BA, Balady GJ, et al. Exercise and acute cardiovascular events placing the risks into perspective: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism and the Council on Clinical Cardiology. Circulation. 2007. 115:2358–2368.
28. Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO. Sudden deaths in young competitive athletes: analysis of 1866 deaths in the United States, 1980-2006. Circulation. 2009. 119:1085–1092.
29. Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G. Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol. 2003. 42:1959–1963.
30. Thompson PD, Funk EJ, Carleton RA, Sturner WQ. Incidence of death during jogging in Rhode Island from 1975 through 1980. JAMA. 1982. 247:2535–2538.
31. Albert CM, Mittleman MA, Chae CU, Lee IM, Hennekens CH, Manson JE. Triggering of sudden death from cardiac causes by vigorous exertion. N Engl J Med. 2000. 343:1355–1361.
32. Maron BJ, Poliac LC, Roberts WO. Risk for sudden cardiac death associated with marathon running. J Am Coll Cardiol. 1996. 28:428–431.
33. Siscovick DS, Ekelund LG, Johnson JL, Truong Y, Adler A. Sensitivity of exercise electrocardiography for acute cardiac events during moderate and strenuous physical activity: the lipid research clinics coronary primary prevention trial. Arch Intern Med. 1991. 151:325–330.
34. Maron BJ, Thompson PD, Ackerman MJ, et al. Recommendations and considerations related to pre-participation screening for cardiovascular abnormalities in competitive athletes: 2007 update: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Foundation. Circulation. 2007. 115:1643–1455.
35. Corrado D, Basso C, Schiavon M, Thiene G. Screening for hypertrophic cardiomyopathy in young athletes. N Engl J Med. 1998. 339:364–369.
36. Corrado D, Basso C, Thiene G. Sudden cardiac death in young people with apparently normal heart. Cardiovasc Res. 2001. 50:399–408.
37. Corrado D, Basso C, Pavei A, Michieli P, Schiavon M, Thiene G. Trends in sudden cardiovascular death in young competitive athletes after implementation of a pre-participation screening program. JAMA. 2006. 296:1593–1601.
38. Luqman N, Sung RJ, Wang CL, Kuo CT. Myocardial ischemia and ventricular fibrillation: pathophysiology and clinical implications. Int J Cardiol. 2007. 119:283–290.
39. Aiba T, Tomaselli GF. Electrical remodeling in the failing heart. Curr Opin Cardiol. 2010. 25:29–36.
40. Akar FG, Yan GX, Antzelevitch C, Rosenbaum DS. Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome. Circulation. 2002. 105:1247–1253.
41. Yano M, Ono K, Ohkusa T, et al. Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure. Circulation. 2000. 102:2131–2136.
42. Yano M, Yamamoto T, Kobayashi S, Ikeda Y, Matsuzaki M. Defective Ca2+ cycling as a key pathogenic mechanism of heart failure. Circ J. 2008. 72:Suppl A. A22–A30.
43. Pogwizd SM, Schlotthauer K, Li L, Yuan W, Bers DM. Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res. 2001. 88:1159–1167.
44. Maron BJ, Spirito P, Shen WK, et al. Implantable cardioverter-defibrillators and prevention of sudden cardiac death in hypertrophic cardiomyopathy. JAMA. 2007. 298:405–412.
45. Cha YM, Gersh BJ, Maron BJ, et al. Electrophysiologic manifestations of ventricular tachyarrhythmias provoking appropriate defibrillator interventions in high-risk patients with hypertrophic cardiomyopathy. J Cardiovasc Electrophysiol. 2007. 18:483–487.
46. Maron BJ. Hypertrophic cardiomyopathy. Lancet. 1997. 350:127–133.
47. Nicod P, Polikar R, Peterson KL. Hypertrophic cardiomyopathy and sudden death. N Engl J Med. 1988. 318:1255–1257.
48. McKenna WJ, Firoozi S, Sharma S. Arrhythmias and sudden death in hypertrophic cardiomyopathy. Card Electrophysiol Rev. 2002. 6:26–31.
49. Ly HQ, Greiss I, Talakic M, et al. Sudden death and hypertrophic cardiomyopathy: a review. Can J Cardiol. 2005. 21:441–448.
50. Zipes DP, Camm AJ, Borggrefe M, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (writing committee to develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation. 2006. 114:e385–e484.
51. Basso C, Maron BJ, Corrado D, Thiene G. Clinical profile of congenital coronary artery anomalies with origin from the wrong aortic sinus leading to sudden death in young competitive athletes. J Am Coll Cardiol. 2000. 35:1493–1501.
52. Barcin C, Kursaklioglu H, Kose S, Amasyali B. Coronary myocardial bridge constitutes a risk: but how to manage it? Int J Cardiol. 2010. 138:215–216.
53. Alegria JR, Herrmann J, Holmes DR Jr, Lerman A, Rihal CS. Myocardial bridging. Eur Heart J. 2005. 26:1159–1168.
54. Plicht B, Rechenberg W, Kahlert P, Buck T, Erbel R. Mitral valve prolapse: identification of high-risk patients and therapeutic management. Herz. 2006. 31:14–21.
55. Hayek E, Gring CN, Griffin BP. Mitral valve prolapse. Lancet. 2005. 365:507–518.
56. Alliot E, Clementy J, Prystowsky E. Fighting sudden cardiac death: a worldwide challenge. 2000. 1st ed. New York: Futura Publishing Co.
57. Munger TM, Packer DL, Hammill SC, Feldman BJ, Bailey KR, Ballard DJ, Holmes DR Jr, Gersh BJ. A population study of the natural history of Wolff-Parkinson-White syndrome in Olmsted County, Minnesota, 1953-1989. Circulation. 1993. 87:866–873.
58. Pappone C, Manguso F, Santinelli R, et al. Radiofrequency ablation in children with asymptomatic Wolff-Parkinson-White syndrome. N Engl J Med. 2004. 351:1197–1205.
59. Wilde AA, Roden DM. Predicting the long-QT genotype from clinical data: from sense to science. Circulation. 2000. 102:2796–2798.
60. Shimizu W, Antzelevitch C. Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. J Am Coll Cardiol. 2000. 35:778–786.
61. Priori SG, Napolitano C, Memmi M, et al. Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation. 2002. 106:69–74.
62. Liu N, Colombi B, Memmi M, et al. Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model. Circ Res. 2006. 99:292–298.
63. Gaita F, Giustetto C, Bianchi F, et al. Short QT Syndrome: a familial cause of sudden death. Circulation. 2003. 108:965–970.
64. Maury P, Extramiana F, Sbragia P, et al. Short QT syndrome: update on a recent entity. Arch Cardiovasc Dis. 2008. 101:779–786.
65. Giustetto C, Di Monte F, Wolpert C, et al. Short QT syndrome: clinical findings and diagnostic-therapeutic implications. Eur Heart J. 2006. 27:2440–2447.
66. Maron BJ, Chaitman BR, Ackerman MJ, et al. Recommendations for physical activity and recreational sports participation for young patients with genetic cardiovascular diseases. Circulation. 2004. 109:2807–2816.
67. Pelliccia A, Di Paolo FM, Corrado D, et al. Evidence for efficacy of the Italian national pre-participation screening programme for identification of hypertrophic cardiomyopathy in competitive athletes. Eur Heart J. 2006. 27:2196–2200.
68. Corrado D, Basso C, Pavei A, Michieli P, Schiavon M, Thiene G. Trends in sudden cardiovascular death in young competitive athletes after implementation of a preparticipation screening program. JAMA. 2006. 296:1593–1601.
69. Corrado D, Pelliccia A, Heidbuchel H, et al. Recommendations for interpretation of 12-lead electrocardiogram in the athlete. Eur Heart J. 2010. 31:243–259.
70. Maron BJ, Pelliccia A. The heart of trained athletes: cardiac remodeling and the risks of sports, including sudden death. Circulation. 2006. 114:1633–1644.
71. Pelliccia A, Maron BJ, De Luca R, Di Paolo FM, Spataro A, Culasso F. Remodeling of left ventricular hypertrophy in elite athletes after long-term deconditioning. Circulation. 2002. 105:944–949.
72. Nishimura T, Yamada Y, Kawai C. Echocardiographic evaluation of long-term effects of exercise on left ventricular hypertrophy and function in professional bicyclists. Circulation. 1980. 61:832–840.
73. Ector J, Ganame J, van der Merwe N, et al. Reduced right ventricular ejection fraction in endurance athletes presenting with ventricular arrhythmias: a quantitative angiographic assessment. Eur Heart J. 2007. 28:345–353.
74. Pelliccia A, Kinoshita N, Pisicchio C, et al. Long-term clinical consequences of intense, uninterrupted endurance training in Olympic athletes. J Am Coll Cardiol. 2010. 55:1619–1625.
75. Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO. Sudden deaths in young competitive athletes: analysis of 1866 deaths in the United States, 1980-2006. Circulation. 2009. 119:1085–1092.
76. Maron BJ, Estes NA 3rd. Commotio cordis. N Engl J Med. 2010. 362:917–927.