Keimyung Med J.  2014 Jun;33(1):71-77. 10.0000/kmj.2014.33.1.71.

Aspergillosis of Central Nervous System in Immunocompetent Host

• Kim HA
• Jung H
• Kim I
• Ryu SY

• KMID: 2224205
• DOI: http://doi.org/10.0000/kmj.2014.33.1.71

Abstract

Aspergillosis of the central nervous system from sinonasal origin is rare in immunocompetent hosts. Due to the rarity of the cases in immunocompetent hosts, only few cases are reported in the previous literature. But, some cases reported diversity of clinical presentations in immunocompetent hosts. Aspergillosis of the central nervous system from sinonasal origin, bony invasion with only orbit or cranial base was more common than intracerebral aspergillosis in immunocompetent hosts. In this type of disease, although maxillary sinus is more commonly involved, sphenoid sinus and clivus are unusual sites for aspergillosis of central nervous system. Because of the anatomical position of sphenoid sinus, it is associated with poor prognosis with intracranial extension. We reported a case of the aspergillosis of central nervous system involving clivus in the immunocompetent host who was misdiagnosed as metastatic tumor or plasmacytoma due to the unusual location and host factor.

Keyword

Brain neoplasm; Immunocompetence; Neuroaspergillosis

MeSH Terms

Aspergillosis*
Brain Neoplasms
Central Nervous System*
Cranial Fossa, Posterior
Immunocompetence
Maxillary Sinus
Neuroaspergillosis
Orbit
Plasmacytoma
Prognosis
Skull Base
Sphenoid Sinus