Keimyung Med J.  2015 Dec;34(2):127-132. 10.0000/kmj.2015.34.2.127.

Pulmonary Mucormycosis Treated Successfully with Posaconazole as Salvage Therapy

Affiliations
  • 1Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. wonylee@yonsei.ac.kr

Abstract

Mucormycosis (formerly known as zygomycosis) is a life-threatening opportunistic mycosis that infects a broad range of hosts with qualitative or quantitative defects in innate immunity. The overall mortality rate of pulmonary mucormycosis is above 70%. The prognosis and outcome of pulmonary mucormycosis have not improved significantly over the last decade, mainly because of difficulty in early diagnosis and the limited activity of current antifungal agents against members of the order Mucorales. We report a case of pulmonary mucormycosis treated successfully with posaconazole as salvage therapy. We suggest that posaconazole may be considered as an alternative therapeutic approach in patients with invasive pulmonary mucormycosis who are unable to tolerate surgical treatment.

Keyword

Mucormycosis; Posaconazole; Salvage therapy

MeSH Terms

Antifungal Agents
Early Diagnosis
Humans
Immunity, Innate
Mortality
Mucorales
Mucormycosis*
Prognosis
Salvage Therapy*
Antifungal Agents
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