J Rheum Dis.  2012 Dec;19(6):351-354. 10.4078/jrd.2012.19.6.351.

A Case of Localized Castleman's Disease in a Patient with Rheumatoid Arthritis

• Choi YJ
• Ku KH
• Kwon HJ
• Park DH
• Kim GT

• KMID: 2223063
• DOI: http://doi.org/10.4078/jrd.2012.19.6.351

Abstract

Castleman's disease is an atypical lymphoproliferative disorder of unknown origin. It has three histologic types (hyaline vascular, plasma-cell, and mixed) and two clinical types (localized and multicentric). Some systemic diseases may be accompanied with Castleman's disease, but it is unclear if Castleman's disease is relevant to rheumatoid arthritis. We experienced a case of Castleman's disease suffering from rheumatoid arthritis. A 25-year-old female with rheumatoid arthritis was referred to our hospital with a palpable mass lesion in the left upper arm. Excisional biopsy of the mass and arthroscopic synovectomy were performed, and the histological finding was compatible with hyaline-vascular type of Castleman's disease. Herein, we report this case along with brief review of relevant literature.

Keyword

Castleman's disease; Rheumatoid arthritis

MeSH Terms

Arm
Arthritis, Rheumatoid
Biopsy
Female
Giant Lymph Node Hyperplasia
Humans
Lymphoproliferative Disorders
Stress, Psychological

Figure

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  Figure 1 (A~C) Ultrasonographic findings of left elbow joint and mass lesion: (A) Synovial hypertrophy with increased vascularity of the left elbow joint, (B, C) Benign natured lymph node with an intact capsule and no abnormal vascularity. (D) Light microscopic findings of mass lesion shows proliferation of lymphoid tissue forming large follicles, containing increased vascular proliferation and hyalinization of their germinal centers. The mass lesion is a giant lymphoid hyperplasia, and is compatible with hyaline-vascular type (H&E, ×200).

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