J Rheum Dis.  2013 Apr;20(2):127-131. 10.4078/jrd.2013.20.2.127.

A Case of ANA-negative, Anti-dsDNA Negative, and Anti-Ro/SSA Positive Membranous Lupus Nephropathy

• Yang HC
• Hong MJ
• Lim JH
• Jang SA
• Jeon SY
• Yoo WH

• KMID: 2223039
• DOI: http://doi.org/10.4078/jrd.2013.20.2.127

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of diverse autoantibodies with various systemic organ involvements. In patients with SLE, autoantibodies, such as antinuclear antibody (ANA) and anti-dsDNA antibody, play an important role not only in diagnosing the disease, but also representing the pathogenesis of the disease. ANA is the main screening tool in diagnosis and serum complement levels and anti-dsDNA antibody level are closely related to the disease activities. Nevertheless, exceptionally, some patients represent with negative ANA and/or anti-dsDNA antibody leading to difficulties in diagnosing the disease. Here, we report a case of 37-year old female SLE patient with negative ANA, negative anti-dsDNA antibody, and positive anti-Ro/SSA antibody, which manifested with nephrotic syndrome.

Keyword

Antinuclear antibody (ANA); Anti-dsDNA antibody; Anti-Ro antibody; Membranous nephropathy; Systemic lupus erythematosus

MeSH Terms

Antibodies, Antinuclear
Autoantibodies
Autoimmune Diseases
Complement System Proteins
Female
Glomerulonephritis, Membranous
Humans
Lupus Erythematosus, Systemic
Mass Screening
Nephrotic Syndrome
Antibodies, Antinuclear
Autoantibodies
Complement System Proteins

Figure

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  Figure 1. Pathologic findings of renal biopsy showed lupus nephritis, class V.

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  Figure 2. Immunofluorescence findings of renal biopsy.

Reference

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