Ann Dermatol.  2009 May;21(2):182-184. 10.5021/ad.2009.21.2.182.

Mycosis Fungoides as an Ichthyosiform Eruption

• Nam KH
• Park J
• Hong JS
• Roh SG
• Kim DS
• Yun SK

• KMID: 2219392
• DOI: http://doi.org/10.5021/ad.2009.21.2.182

Abstract

Ichthyosiform eruption as a specific manifestation of mycosis fungoides is very rare and only a few such cases have currently been reported in the medical literature. A 63- year-old Korean man presented with a 4-year history of a pruritic ichthyotic eruption. There was no personal or family history of ichthyosis or atopy. The ichthyosiform skin changes involved the abdomen, arms, thighs and shins. The face, palms and soles were spared. There was no peripheral lymphadenopathy or organomegaly. The typical lesions of mycosis fungoides were not present. The results of the routine investigations were normal or negative. A skin biopsy specimen revealed the findings of early mycosis fungoides. He was successfully treated with photochemotherapy.

Keyword

Ichthyosis; Mycosis fungoides

MeSH Terms

Abdomen
Arm
Biopsy
Humans
Ichthyosis
Lymphatic Diseases
Mycosis Fungoides
Skin
Thigh

Figure

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  Fig. 1 Poorly defined irregular and polygonal scales on the abdomen.

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  Fig. 2 The biopsy specimen shows a compact, thick orthokeratosis, a thinned epidermis with a slightly decreased granular layer and an upper dermal mononuclear cell infiltrate with Pautrier's microabscess in the epidermis (H&E, ×400).

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  Fig. 3 PCR product run on SSCP gel. Lane 1: molecular weight marker. Lane 2 and Lane 3 show the Vγ1-8 and Vγ11 PCR products from the case, respectively. A well-defined monoclonal pattern was produced with the Vγ1-8 primer. The polyclonal control produced the pattern of smears in lane 4.

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