Korean J Med.  2016 Jun;90(6):545-549. 10.3904/kjm.2016.90.6.545.

De Novo AL Amyloidosis in a Renal Allograft

Affiliations
  • 1Department of Internal Medicine, Maryknoll Hospital, Busan, Korea. egis70@naver.com
  • 2Division of Nephrology, Department of Internal Medicine, Maryknoll Hospital, Busan, Korea.

Abstract

Amyloidosis is characterized by the extracellular deposition of amyloid in various tissues and organs, particularly the kidney and heart. The estimated incidence of systemic amyloidosis is at least 8 per million population per year. However, few cases of systemic amyloidosis in renal allografts have been reported. A stable renal transplant recipient was admitted with proteinuria and dyspnea on exertion. The M-peak was found on serum and urine protein electrophoresis, and lambda (λ) dominance was confirmed by serum and urine free-light-chain test. The patient was diagnosed with systemic amyloidosis of a renal allograft, by allograft biopsy, at 22 years after renal transplantation. We report a case of AL amyloidosis in a stable renal allograft and review the medical literature.

Keyword

De novo AL amyloidosis; Kidney allograft; Kidney biopsy; Immunoglobulin light chains

MeSH Terms

Allografts*
Amyloid
Amyloidosis*
Biopsy
Dyspnea
Electrophoresis
Heart
Humans
Immunoglobulin Light Chains
Incidence
Kidney
Kidney Transplantation
Proteinuria
Transplant Recipients
Amyloid
Immunoglobulin Light Chains
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