J Korean Ophthalmol Soc.  2013 Nov;54(11):1794-1799. 10.3341/jkos.2013.54.11.1794.

Rapidly Progressive Endogenous Endophthalmitis with Subretinal Abscess

• Kim HA
• Choi KS

• KMID: 2217930
• DOI: http://doi.org/10.3341/jkos.2013.54.11.1794

Abstract

PURPOSE
To report a case of a rapidly progressive endogenous endophthalmitis with subretinal abscess that involved the macula and was treated with early vitrectomy.
CASE SUMMARY
A 42-year-old man with liver cirrhosis, hepatic cellular carcinoma and diabetes, who underwent regular fundus checkup for diabetic retinopathy presented with reduced vision, ocular pain in the left eye and headache. Indirect ophthalmoscopy showed subretinal abscess approximately five times the optic disc size and surrounding retinal hemorrhage in the nasal upper quadrant. A provisional diagnosis of bacterial endophthalmitis was made based on systemic disease and funduscopic findings. Treatment with topical and systemic empirical antibiotics was initiated along with intravitreal vancomycin and ceftazidime injection. Despite the treatment, after 24 hours the abscess size increased to approximately 10 times the optic disc size and began to involve the macula. The patient underwent diagnostic and therapeutic pars plana vitrectomy as well as vitreous and abscess content cultures. MRSA was found in a blood culture test. Five days postoperatively, the patient's vision and symptoms improved significantly and the residual lesion was cleared, with retinal scars.
CONCLUSIONS
In a patient with endogenous endophthalmitis with subretinal abscess, presence of macular invasion and rate of progression is important in determining the time and method of operation. In this case, early vitrectomy was a good choice to preserve macular structure and the patient's visual acuity.

Keyword

Early vitrectomy; Endophthalmitis; Subretinal abscess

MeSH Terms

Abscess*
Adult
Anti-Bacterial Agents
Blood
Ceftazidime
Diabetic Retinopathy
Diagnosis
Endophthalmitis*
Headache
Humans
Liver Cirrhosis
Methicillin-Resistant Staphylococcus aureus
Ophthalmoscopy
Retinal Hemorrhage
Retinaldehyde
Vancomycin
Vision, Low
Vision, Ocular
Visual Acuity
Vitrectomy
Anti-Bacterial Agents
Ceftazidime
Retinaldehyde
Vancomycin

Figure

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  Figure 1. Serial fundus photographs 3 months before (A), at the first visit after symtom begin (B), 24 hours after intravitreal antibiotics injection (C), 5 days after vitrctomy (D). Some generalized microaneurysmmm and cotton wool spots are visible. (A) A round, elevated yellowish mound lesion about 5 times of optic disc-sized lesion with retinal hemorrhages (B) was worsened, increased size about 10 times of optic disc-sized, involving macula (C). Fundus photograph after vitrectomy shows flattened lesion covered with translucent yellowish membrane, surrounded laser photocoagulation.

• 

  Figure 2. Fluorescein angiography and indocyanin green angiography show masking effect (subretinal abscess) and early hyperfluorescence which is increased until late phase, active leakage around lesion and optic disc.

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  Figure 3. Optical coherence tomography (OCT) showed the localization of the mass, protruding into vitreal cavity underneath retinal pigment epithelium (A). Despite intravitreal antibiotics injection, abscess increased to about 10 times the size of the optic disc, began to involve the macula (B). After surgery, flattened retina without retinal detachment or subretinal fluids and restored continuity with adjacent normal tissues at abscess lesion (C), and macular (D).

Reference

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