J Korean Ophthalmol Soc.  2013 Jun;54(6):857-861. 10.3341/jkos.2013.54.6.857.

Cognitive Function Evaluation by Mini-Mental State Examination-Korea in Essential Blepharospasm

• Chung SJ
• Lew H

• KMID: 2217260
• DOI: http://doi.org/10.3341/jkos.2013.54.6.857

Abstract

PURPOSE
The present study evaluated cognitive functions of Korean patients with essential blepharospasm by the Mini Mental State Examination - Korea (MMSE-K).
METHODS
Atotal of 33 patients diagnosedwith essential blepharospasm were evaluated. Using the K-MMSEcognitive functions such as orientation, registration and recall, attention and calculation, language, comprehension, and decision were evaluated.
RESULTS
All patients were alert and orientedwith an average K-MMSEscore of 25.2 +/- 4.0 points. The normal group scores were above 24 points in 25 patients (75%), suspected dementia scores were from 20 to 23 points in 5 patients (15%), and definite dementia scores were from 15 to 19 points in 3 patients (9%). Neurologic and brain imaging evaluation was performed in the 8 patients with suspected dementia or definite dementia. Among these patients, 2 were diagnosed with Parkinson's disease, 2 were shown to have a specific brain lesion on magnetic resonance imaging, and 1 was diagnosed with a stroke and treated with antiplatelet therapy.
CONCLUSIONS
The K-MMSE can be a helpful tool for the early detection of cognitive dysfunction in outpatients with essential blepharospasm.

Keyword

Cognitive function; Essential blepharospasm; Mini mental state examination

MeSH Terms

Blepharospasm
Brain
Comprehension
Dementia
Humans
Korea
Magnetic Resonance Imaging
Neuroimaging
Orientation
Outpatients
Parkinson Disease
Stroke

Reference

References

1. Henderson JW. Essential blepharospasm. Trans Am Ophthalmol Soc. 1956; 54:453–520.

2. Kim JC, Kim WS, Ahn SK, Shin KH. Clinical studies in patients with essential blepharospasm and with hemifacial spasm. J Korean Ophthalmol Soc. 1991; 32:837–43.

3. Alexander GE, Crutcher MD. Functional architecture of basal gan-glia circuits: neural substrates of parallel processing. Trends Neurosci. 1990; 13:266–71.

4. Horie C, Suzuki Y, Kiyosawa . . Decreased dopamine D re-ceptor binding in essential blepharospasm. Acta Neurol Scand. 2009; 119:49–54.

5. Micheli F, Scorticati MC, Folgar S, Gatto E. Development of Parkinson's disease in patients with blepharospasm. Mov Disord. 2004; 19:1069–72.

6. Ross AH, Elston JS, Marion MH, Malhotra R. Review and update of involuntary facial movement disorders presenting in the oph-thalmological setting. Surv Ophthalmol. 2011; 56:54–67.

7. Erixon-Lindroth N, Farde L, Wahlin TB. . The role of the stria-tal dopamine transporter in cognitive aging. Psychiatry Res. 2005; 138:1–12.

8. Relja M, Klepac N. A dopamine agonist, pramipexole, and cognitive functions in Parkinson’s disease. J Neurol Sci. 2006; 248:251–4.

9. Bales JW, Wagner AK, Kline AE, Dixon CE. Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis. Neurosci Biobehav Rev. 2009; 33:981–1003.

10. Chou YH, Huang WS, Su TP. . Dopamine transporters and cog-nitive function in methamphetamine abuser after a short abstinence: A SPECT study. Eur Neuropsychopharmacol. 2007; 17:46–52.

11. Alemán GG de, Erausquin GA, Micheli F. Cognitive disturbances in primary blepharospasm. Mov Disord. 2009; 24:2112–20.

12. Dias FM, Doyle FC, Kummer A. . Executive functioning in patients with blepharospasm in comparison with patients with hemi-facial spasm. Arq Neuropsiquiatr. 2009; 67:12–5.

13. Anderson RL, Patel BC, Holds JB, Jordan DR. Blepharospasm : past, present and future. Ophthal Plast Reconstr Surg. 1998; 14:305–17.

14. Scott AB, Kennedy RA, Stubbs HA. Botumlinum A toxin injection as a treatment for blepharospasm. Arch Ophthalmol. 1985; 103:347–50.

15. Yu SB, Lew H, Yun YS. Therapeutic effect of Botulinum toxin in-jection in eyelid myokymia patients. J Korean Ophthalmol Soc. 2007; 6:749–54.

16. Shin JH, Jeon C, Woo KI, Kim YD. Clinical comparability of dys-port and Botox in essential blepharospasm. J Korean Ophthalmol Soc. 2009; 50:331–5.

17. Lee TS, Choi JS, Kim JS. Clinical effect of limited myectomy for the treatment of essential blepharospasm. J Korean Ophthalmol Soc. 2004; 45:1783–9.

18. Berardelli A, Rothwell JC, Hallet M. . The pathophysiology of primary dystonia. Brain. 1998; 121:1195–212.

19. Dauer WT, Burke RE, Greene P, Fahn S. Current concepts on the clinical features, aetiology and management of idiopathic cervical dystonia. Brain. 1998; 121:547–60.

20. Vitek JL. Pathophysiology of dystonia: a neuronal model. Mov Disord. 2002; 17:S49–62.

21. Kim JM, Shin IS, Yoon JS, Lee HY. Comparison of diagnostic val-idities between MMSE-K and K-MMSE for screening of dementia. J Korean Neuropsychiatr Assoc. 2003; 42:124–30.

22. Woo JI, Lee JH, Yoo KY. . Prevalence of dementia in the elderly residents of a rural community in Korea. J Korean Neuropsychiatr Assoc. 1997; 36:92–102.