J Korean Ophthalmol Soc.  2013 Feb;54(2):331-337. 10.3341/jkos.2013.54.2.331.

Analysis of Retinal Nerve Fiber Layer Thickness of Superior Segmental Optic Hypoplasia and Normal-Tension Glaucoma

• Kim JH
• Kang SH
• Park JH
• Yi K

• KMID: 2216671
• DOI: http://doi.org/10.3341/jkos.2013.54.2.331

Abstract

PURPOSE
To analyze the peripapillary retinal nerve fiber layer (RNFL) in superior segmental optic hypoplasia (SSOH) patients and normal tension glaucoma (NTG) patients with inferior visual field defects using optical coherence tomography (OCT).
METHODS
Ten eyes of 10 patients with SSOH and 10 eyes of 10 patients with NTG were evaluated. The peripapillary RNFL thickness measured by OCT was compared between the 2 groups.
RESULTS
The mean RNFL thickness was not significantly different between SSOH patients (79.60 +/- 12.54 micrometer) and NTG patients (77.10 +/- 8.52 micrometer) (p = 0.089). Among the quadrant parameters, there were no significant differences between the 2 groups (p > 0.05). In a clock-hour analysis, the peripapillary RNFL thickness of the NTG group was significantly thicker than the SSOH group in 12, 1, and 2 o'clock (p = 0.029, 0.007, 0.043, respectively). In contrast, the peripapillary RNFL thickness of the SSOH group was significantly thicker than the SSOH group in 6, and 7 o'clock (p = 0.029, 0.007, respectively).
CONCLUSIONS
Peripapillary RNFL thickness in patients with SSOH was thinner than in those with NTG in the superonasal region, but thicker in the inferotemporal region indicating a different retinal nerve fiber defect pattern between the 2 diseases.

Keyword

Nerve hypoplasia; Optic hypoplasia; Optic nerve; Superior segmental optic hypoplasia (SSOH)

MeSH Terms

Eye
Glaucoma
Humans
Low Tension Glaucoma
Nerve Fibers
Optic Nerve
Retinaldehyde
Tomography, Optical Coherence
Visual Fields
Retinaldehyde

Figure

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  Figure 1. A patient with superior segmental optic hypoplasia (SSOH). Representative color disc photograph (A) and retinal nerve fiber layer (RNFL) photograph (B) showing neuroretinal thinning of the superior nasal region with corresponding RNFL defects. (C) Humphrey automated perimetry shows a characteristic inferior visual field defect. (D) Optical coherence tomography (OCT) scan shows the peripapillary RNFL thinning in superior region of the left eye.

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  Figure 2. Three examples with superior segmental optic hypoplasia (SSOH). Color fundus photograph and retinal nerve fiber layer (RNFL) photograph show optic disc rim thinning in the superior and superonasal segments (A, B, C).

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  Figure 3. The peripapillary retinal nerve fiber layer (RNFL) thickness assessed by optical coherence tomography is shown for clock hour around the optic nerve head. Solid triangles represent mean RNFL thickness from 10 eyes with superior segmental optic hypoplasia (SSOH) and solid squares represent normal tension glaucoma (NTG) patients. Error bars indicate 1 standard deviation from the mean. Asterisks indicate the clock hours that show significant difference of RNFL thickness between NTG and SSOH patients (p < 0.05).

Reference

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