J Korean Ophthalmol Soc.  2015 Jan;56(1):6-12. 10.3341/jkos.2015.56.1.6.

Relationship between Dry Eye Parameters and Anterior Corneal Higher-Order Aberrations Measured by Two Different Instruments

• Cho AR
• Kang NH
• Jun RM

• KMID: 2216147
• DOI: http://doi.org/10.3341/jkos.2015.56.1.6

Abstract

PURPOSE
To compare the corneal first surface higher-order aberrations (HOAs) of normal subjects and patients with dry eye using KR-1W(R) (Topcon Corp., Tokyo, Japan) and Pentacam(R) HR (Oculus Inc., Dutenhofen, Germany). We analyzed the relationship between the aberrations and the diagnostic parameters of dry eye.
METHODS
We evaluated anterior corneal HOAs in 71 normal eyes and 71 dry eyes using KR-1W(R) and Pentacam(R). Dry eye patients were examined for fluorescein staining, tear break-up time (TBUT), and Schirmer I test. Ocular Surface Disease Index (OSDI) was used for assessment of subjective symptoms in dry eye patients.
RESULTS
HOAs measured by both instruments were greater in the dry eye group than in the control group, although HOAs using KR-1W(R) only achieved statistical significance. The anterior corneal HOAs measured by the 2 instruments were significantly correlated with superficial punctate keratitis. Moreover, TBUT and the Shirmer I test negatively correlated, and OSDI positively correlated, with anterior corneal HOAs.
CONCLUSIONS
The HOAs in patients with dry eye were significantly different from controls and tended to increase with disease severity. KR-1W(R) might be more useful than Pentacam(R) to detect tear film instabilities.

Keyword

Anterior corneal higher-order aberrations; Dry eye; HOAs; KR-1W(R); Pentacam(R)

MeSH Terms

Fluorescein
Humans
Keratitis
Tears
Fluorescein

Figure

• 

  Figure 1. Comparison of the HOAs of dry eye group to the control group using KR-1W® (A) and Pentacam® (B). HOAs = high-er-order aberrations; 2˚ Astig. = secondary astigmatism; SA = spherical aberration. * p < 0.05 based on independent sample t-test between the dry eyes and control group.

• 

  Figure 2. Comparison of HOAs between KR-1W® and Pentacam® in normal (A) and dry eye groups (B). HOAs = higher-order aberrations; 2˚ Astig. = secondary astigmatism; SA = spherical aberration. * p < 0.05 based on independent sample t-test between the dry eyes and control group.

• 

  Figure 3. Correlation coefficients between 4 parameters and higher-order aberrations (HOAs) measured by KR-1W® (A) and Pentacam® (B) in the dry eye group. T_HOAs = total HOAs; 3rd_HOAs = third HOAs; 4th_HOAs = fourth HOAs; 2˚ Astig. = secondary astigmatism; SA = spherical aberration; TBUT = tear break-up time; OSDI = ocular surface disease index. * p < 0.05 based on Spearman’s correlation coefficient.

Reference

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