J Korean Ophthalmol Soc.  2011 Jul;52(7):832-837. 10.3341/jkos.2011.52.7.832.

Posterior Subtenon Triamcinolone Acetonide Injection for Refractory Diabetic Macular Edema in Vitrectomized Eye

• Lee JH
• Park HJ
• Lee JE
• Oum BS

• KMID: 2214708
• DOI: http://doi.org/10.3341/jkos.2011.52.7.832

Abstract

PURPOSE
To evaluate the effect of posterior subtenon injection of triamcinolone acetonide (TA) in patients with refractory diabetic macular edema (DME) after vitrectomy.
METHODS
Seventeen vitrectomized eyes in 16 patients with DME underwent a posterior subtenon injection of TA (40 mg/1.0 ml) and were followed-up for more than six months. Visual acuity (VA, logMAR) and central subfield macular thickness (CSMT, microm) according to optical coherent tomography were assessed at baseline and 1, 3, and 6 months after an injection of TA.
RESULTS
The patients included four men and 12 women with an average age of 56.9 years. VA improved significantly from 0.70 +/- 0.33 (mean +/- SD) before injection to 0.56 +/- 0.24 one month and 0.54 +/- 0.21 three months after an injection of TA. Visual acuity at six months was 0.61 +/- 0.24 and had no significance (p = 0.17). CSMT decreased significantly from 469 +/- 145 before injection to 323 +/- 58, 343 +/- 100, and 389 +/- 156 one, three, and six months after an injection of TA, respectively.
CONCLUSIONS
Posterior subtenon injection of TA is effective in the short-term for improving VA and CMT in patients with refractory diabetic macular edema after vitrectomy.

Keyword

Diabetic macular edema; Posterior subtenon injection; Triamcinolone acetonide; Vitrectomy

MeSH Terms

Eye
Female
Humans
Macular Edema
Male
Triamcinolone
Triamcinolone Acetonide
Visual Acuity
Vitrectomy
Triamcinolone
Triamcinolone Acetonide

Figure

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  Figure 1. Changes in mean visual acuity (LogMAR) in patients after posterior sub-Tenon injection of triamcinolone acetonide for diabetic macular edema in vitrectomized eyes (* p < 0.05).

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  Figure 2. Changes in mean central subfield macular thickness in patients after posterior sub-Tenon injection of triamcinolone acetonide for diabetic macular edema in vitrectomized eye (*p < 0.05).

Reference

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