J Korean Ophthalmol Soc.  2011 May;52(5):557-565. 10.3341/jkos.2011.52.5.557.

Visual Field Cluster Map Corresponding to Retinal Nerve Fiber Layer Sectors in Glaucoma

• Hwang JH
• Uhm KB

• KMID: 2214575
• DOI: http://doi.org/10.3341/jkos.2011.52.5.557

Abstract

PURPOSE
To generate a map relating visual field (VF) test points to corresponding areas of the retinal nerve fiber layer (RNFL) measured with optical coherence tomography (OCT) in patients with localized RNFL defects.
METHODS
Twenty-four patients with preperimetric glaucoma and 173 patients with perimetric glaucoma, all with localized RNFL defects, underwent standard automated perimetry (SAP) and OCT measurements. To define zones of related point, factor analysis of the mean thresholds for the SAP test points was performed, independently for each hemifield. A map relating the VF zones to the 12 OCT sectors was plotted based on the strongest correlations between both techniques.
RESULTS
Factor analysis divided the VF points into five VF zones for each hemifield. Distribution of the VF zones for the superior and inferior hemifields was slightly asymmetric. Linear regression results showed that superior VF zones corresponding to the superior arcuate and nasal step regions were best correlated with 6- and 7-o'clock RNFL sectors (inferior and inferior temporal) of thickness (r = 0.51-0.59). RNFL thinning (defined by abnormal sector at p < 5%) and regional decreases in SAP sensitivity (defined by abnormal pattern deviation at p < 5%) were topographically related.
CONCLUSIONS
A newly developed VF cluster map revealed significant topographical structure-function relationships, especially in the arcuate and nasal step region of the VF.

Keyword

Factor analysis; Glaucoma; Optical coherence tomography; Retinal nerve fiber layer; Visual field map

MeSH Terms

Factor Analysis, Statistical
Glaucoma
Humans
Linear Models
Nerve Fibers
Retinaldehyde
Tomography, Optical Coherence
Visual Field Tests
Visual Fields
Retinaldehyde

Figure

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  Figure 1. The angular locations of photographic localized retinal nerve fiber layer (RNFL) defects in the right eye.

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  Figure 2. Each of the test points of the C 24-2 was numbered for the factor analysis.

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  Figure 3. Factor analysis generated the visual field points into five visual field zones for each hemifield. The diagram is for the right eye.

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  Figure 4. Scatterplots of 7 clock-hour (inferior temporal) peripapillary retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography against visual field zone 3 (superior paracentral) sensitivity (or differential light sensitivity, DLS), expressed in the decibel scale (dB) (A) and in the antilog (1/Lambert) scale (B) in all eyes. VF = visual field.

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  Figure 5. Diagram represent the percentage of the depressed points of p < 5% in the pattern deviation plot (A) and the percentage of optical coherence tomography retinal nerve fiber layer thickness p < 5% for each clock hour (B). The diagram is for the right eye.

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  Figure 6. A new topographic visual field map generated from data in this study. Test points of the visual field were divided by the factor analysis. Visual field zones to corresponding clock-hour sectors measured with optical coherence tomography are shown (A). The corresponding sectors of the optic nerve head for visual field test points according to the results of the Garway-Heath et al study (B). The diagram is for the right eye.

Reference

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