J Korean Ophthalmol Soc.
2010 Nov;51(11):1528-1531. 10.3341/jkos.2010.51.11.1528.
Acyclovir-induced Acute Renal Failure in a Patient With Suspected Acute Retinal Necrosis Syndrome
- Affiliations
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- 1Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. ophkim@hallym.or.kr
- 2Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
- KMID: 2213991
- DOI: http://doi.org/10.3341/jkos.2010.51.11.1528
Abstract
- PURPOSE
To report a case of acyclovir-induced acute renal failure (ARF) suspected as acute retinal necrosis syndrome.
CASE SUMMARY
The authors report a 55-year-old male patient who presented with left eye visual disturbance due to suspected acute retinal necrosis syndrome. Non-oliguric ARF developed after the infusion of intravenous acyclovir (850 mg every 8 hours). The patient did not show any uremic symptoms or signs. The crystal was not discovered in the urine. After stopping the acyclovir infusion and hydration, acyclovir-induced ARF was reversed.
CONCLUSIONS
Although possessing critical nephrotoxicity, acyclovir is a useful antiviral drug. Therefore, when using acyclovir, the importance of hydration and preventing acyclovir-induced ARF should be considered.
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