J Korean Ophthalmol Soc.  2010 Nov;51(11):1471-1478. 10.3341/jkos.2010.51.11.1471.

Correlation Between Nocturnal Dip and Progression of Glaucoma

• Seo HR
• Ryu WY
• Rho SH

• KMID: 2213972
• DOI: http://doi.org/10.3341/jkos.2010.51.11.1471

Abstract

PURPOSE
To investigate the effect of nocturnal dip influence on the progression of glaucomatous visual field defect.
METHODS
We performed 24hr ABPM and V/F tests on patients diagnosed with NTG (140 patients, 280 eyes) and POAG (84 patients, 168 eyes). Nocturnal dips below 10% were classified as non-dippers, and those above 10% were noted as dippers. The correlations among nocturnal dip, progression of glaucomatous visual field defect, and hypertension treatment were examined.
RESULTS
In NTG, dippers in both systolic and diastolic blood pressure furthered glaucomatous visual field defects, with a relative risk of approximately three times that of non-dippers. Hypertension treatment was not influenced by the progression of glaucomatous visual field defect but was influenced by dips in the systolic and diastolic pressures in NTG and in diastolic pressure in POAG. Nocturnal dips were more frequent in the group with progression of the visual field compared to those in the group with non-progression of the visual field in NTG.
CONCLUSIONS
Dipper caused a progression of glaucomatous visual field defects in NTG and was influenced by hypertension treatment in NTG and POAG. Performing 24hr ABPM should be helpful for glaucoma patients with progression of a glaucomatous visual field defect even when the IOP is less than the target pressure. In addition, hypertension treatment should be considered an important factor in the treatment of glaucoma.

Keyword

Dipper; Hypertension treatment; Nocturnal dip; Progression of visual field defect; 24-hour blood pressure monitoring

MeSH Terms

Blood Pressure
Glaucoma
Humans
Hypertension
Salicylates
Visual Fields
Salicylates

Reference

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