J Korean Ophthalmol Soc.  2009 Jan;50(1):99-104. 10.3341/jkos.2009.50.1.99.

Risk Factors of Intraocular Pressure (IOP) Changes in Pseudoexfoliation (PEX) Syndrome

Affiliations
  • 1Department of Ophthalmology, St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea. nhbaek@catholic.ac.kr

Abstract

PURPOSE
We evaluated the short and long-term changes of intraocular pressure (IOP) and studied its risk factors in pseudoexfoliation (PEX).
METHODS
A total of 40 eyes that had been newly diagnosed with PEX from January 1, 1995 to December 31, 2007 were included in this study. Age, gender and accompanying systemic disease were recorded. In addition, the age, gender, number of antiglaucoma eye drops, history of cataract operation, and history of systemic disease were evaluated as risk factors for IOP elevation during the follow-up periods. Pre and post cataract operation IOP was checked to evaluate the effect of the cataract operation on IOP.
RESULTS
The risk factors for IOP elevation in patients newly diagnosed with PEX were old age and female gender. After treatment, a long follow-up period and number of eyedrops were risk factors for IOP elevation. The cataract operation had a one year IOP control effect, especially in cases where the pre operative IOP was greater than 21 mmHg. Over the long term, however, the IOP control effect of cataract surgery could not be determined.
CONCLUSIONS
IOP increased as result of increased patient age. Phacoemulsification was a protective factor for IOP elevation and may be a good method for short-term IOP control.

Keyword

Cataract; Intraocular pressure (IOP); Phacoemulsification; Pseudoexfoliation; Risk factors

MeSH Terms

Cataract
Eye
Female
Follow-Up Studies
Humans
Intraocular Pressure
Ophthalmic Solutions
Phacoemulsification
Risk Factors
Ophthalmic Solutions

Reference

References

1. Ritch R, Schlotzer-Schrehardt U. Exfoliation (pseudoexfoliation) syndrome: toward a new understanding. Proceedings of the First International Think Tank. Acta Ophthalmol Scand. 2001; 79:213–7.
2. Jonasson F, Damji KF, Arnarsson A, et al. Prevalence of open-angle glaucoma in Iceland: Reykjavik Eye Study. Eye. 2003; 17:747–53.
Article
3. Cashwell LF Jr, Shields MB. Exfoliation syndrome. Prevalence in a southeastern United States population. Arch Ophthalmol. 1988; 106:335–6.
Article
4. Hiller R, Sperduto RD, Krueger DE. Pseudoexfoliation, intraocular pressure, and senile lens changes in a population based survey. Arch Ophthalmol. 1982; 100:1080–2.
5. Kozart DM, Yanoff M. Intraocular pressure status in 100 consecutive patients with exfoliation syndrome. Ophthalmology. 1982; 89:214–8.
Article
6. Henry JC, Krupin T, Schmitt M, et al. Long-term follow-up of pseudoexfoliation and the development of elevated intraocular pressure. Ophthalmology. 1987; 94:545–52.
Article
7. Choi J, Park KH. Clinical characteristics of Korean patients with pseudoexfoliation syndrome. J Korean Ophthalmol Soc. 2006; 47:577–86.
8. Ball SF. Exfoliation prevalence in the glaucoma population of South Louisiana. Acta Ophthalmol. 1988; 184:93–8.
9. Mizuno K, Muroi S. Cycloscopy of pseudoexfoliation. Am J Ophthalmol. 1979; 87:513–8.
Article
10. Aasved H. Intraocular pressure in eyes with and without fibrillopathia epitheliocapsularis. Acta Ophthalmol. 1971; 49:601–10.
Article
11. Kivelä T, Hietanen J, Uusitalo M. Autopsy analysis of clinically unilateral exfoliation syndrome. Invest Ophthalmol Vis Sci. 1997; 38:2008–15.
12. Kozobolis VP, Papatzanaki M, Vlachonikolis IG, et al. Epidemiology of pseudoexfoliation in the island of Crete (Greece). Acta Ophthalmol. 1997; 75:726–9.
Article
13. Ringvold A, Blika S, Elsås T, et al. The Middle-Norway Eye-Screening Study. II. Prevalence of simple and capsular glaucoma. Acta Ophthalmol. 1991; 69:273–80.
14. Abdul-Rahman AM, Casson RJ, Newland HS, et al. Pseudoexfoliation in a rural Burmese population: the Meiktila Eye Study. Br J Ophthalmol. 2008; 92:1325–8.
Article
15. Mierzejewski A, Eliks I, Kałuzny B, et al. Cataract phacoemulsification and intraocular pressure in glaucoma patients. Klin Oczna. 2008; 110:11–7.
16. Shingleton BJ, Heltzer J, O'Donoghue MW. Outcomes of phacoemulsification in patients with and without pseudoexfoliation syndrome. J Cataract Refract Surg. 2003; 29:1080–6.
Article
17. Damji KF, Konstas AG, Liebmann JM, et al. Intraocular pressure following phacoemulsification in patients with and without exfoliation syndrome: a 2 year prospective study. Br J Ophthalmol. 2006; 90:1014–8.
Article
18. Streho M, Rohart C, Guigui B, et al. Pseudoexfoliation syndrome in cataract surgery. Retrospective study of 37 cases. J Fr Ophtalmol. 2008; 31:11–5.
19. Grødum K, Heijl A, Bengtsson B. Riskof glaucoma in ocular hypertension with and without pseudoexfoliation Ophthalmology. 2005; 112:386–90.
20. Mitchell P, Wang JJ, Hourihan F. The relationship between glaucoma and pseudoexfoliation: The Blue Mountains Eye Study. Arch Ophthalmol. 1999; 117:1319–24.
21. Shimizu K, Kimura Y, Aoki K. Prevalence of exfoliation syndrome in the Japanese. Acta Ophthalmol. 1988; 184:S112–5.
Article
22. Forsius H. Exfoliation syndrome in various ethnic populations. Acta Ophthalmol. 1988; 184:S71–85.
Article
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