J Korean Soc Med Inform.  2009 Jun;15(2):209-216. 10.4258/jksmi.2009.15.2.209.

Registration of Cadaver's Sectioned Images to Patient's Head MRIs

• Park JS
• Park HS
• Shin DS
• Chung MS
• Kim Y
• Park J
• Shin BS

• KMID: 2211390
• DOI: http://doi.org/10.4258/jksmi.2009.15.2.209

Abstract

OBJECTIVE
Cadaver's sectioned images with high resolution and real color could be used as the source of realistic three-dimensional images. If the sectioned images are registered to a patient's MRIs, three-dimensional images with high resolution and real color that fit the patient, can be produced; the three-dimensional images enable realistic virtual surgery for the patient. The objective of this study was to verify the registration of a cadaver's sectioned images to a patient's head MRIs. METHODS: The sectioned images of the heads of cadaver were associated with segmented images selected at 3 mm intervals. The patient had his head MR scanned at 3 mm intervals; the MRIs were segmented. Software to register the cadaver's sectioned images to the patient's MRIs was developed. On this software, the corresponding dots were identified on both the sectioned images and the MRIs either manually or automatically using segmented images. RESULTS: The registered sectioned images corresponded to the patient's MRIs. Both manual and automatic registrations were satisfied. CONCLUSION: Further study is needed for registering sectioned images to actual patients.

Keyword

Sectioned Images; MRIs; Head; Manual Registration; Automatic Registration

MeSH Terms

Cadaver
Head
Humans
Imaging, Three-Dimensional

Figure

• 

  Figure 1 Feature of the registration software. Sectioned image (left top), MRI (left bottom), registered sectioned image (right bottom), scroll bar to select a couple of images and radio button to select manual or automatic registration (right top)

• 

  Figure 2 Manual registration. Both sectioned image and MRI with the corresponding dots pointed on the skins (left two); registered sectioned image (right)

• 

  Figure 3 Automatic registration based on bone. Segmented sectioned image (left) and segmented MRI (center) with dots pointed on the skull; registered segmented sectioned image (right)

• 

  Figure 4 Inadequate automatic registration based on cerebrum. Segmented sectioned image (left) and segmented MRI (center) with dots pointed on the cerebrum registered segmented sectioned image (right)

• 

  Figure 5 Inadequate manual registration due to few corresponding dots (top row) or incorrectly pointed corresponding dots (bottom row). Both sectioned images and MRIs with corresponding dots pointed (left two columns); registered sectioned images (right column)

• 

  Figure 6 Inadequate registration due to rigid registration algorithm. Sectioned image (left), MRI (center), registered sectioned image (right)

Reference

1. Park JS, Chung MS, Hwang SB, Lee YS, Har DH, Park HS. Visible Korean Human: improved serially sectioned images of the entire body. IEEE Trans Med Imaging. 2005. 24:352–360.

2. Park JS, Chung MS, Hwang SB, Shin BS, Park HS. Visible Korean Human: its techniques and applications. Clin Anat. 2006. 19:216–224.

3. Park JS, Chung MS, Shin BS, Kwon KJ. Manufacture of the serially sectioned images of the whole body (Fifth report: methods for manufacture of the three dimensional images and virtual dissection software). Korean J Anat. 2004. 37:175–190.

4. Li L, Liu YX, Song ZJ. Three-dimensional reconstruction of registered and fused Chinese Visible Human and patient MRI images. Clin Anat. 2006. 19:225–231.

5. Park JS, Chung MS, Hwang SB, Lee YS, Har DH. Technical report on semiautomatic segmentation using the Adobe Photoshop. J Digit Imaging. 2005. 18:333–343.

6. Spitzer VM, Ackerman MJ, Scherzinger AL, Whitlock DG. The Visible Human Male. A technical report. J Am Med Inform Assoc. 1996. 3:118–130.

7. Zhang SX, Heng PA, Liu ZJ. Chinese Visible Human Project. Clin Anat. 2006. 19:204–215.

8. Van De Graaff KM. Human anatomy. 1998. 5th ed. Boston: WCB McGraw-Hill;27761–762.

9. Park JS, Shin DS, Chung MS, Hwang SB, Chung J. Technique of semiautomatic surface reconstruction of the Visible Korean Human data using commercial software. Clin Anat. 2007. 20:871–879.