J Korean Ophthalmol Soc.  2007 Oct;48(10):1433-1437. 10.3341/jkos.2007.48.10.1433.

Bilateral Central Retinal Vein Occlusion in Primary Antiphospholipid Syndrome

• Kim SH
• Kim JY

• KMID: 2211001
• DOI: http://doi.org/10.3341/jkos.2007.48.10.1433

Abstract

PURPOSE: To Report a case of bilateral central retinal vein occlusion (CRVO) caused by primary antiphospholipid syndrome.
METHODS
A 38-year-old male is referred to the department of ophthalmology for the bilateral visual loss.
RESULTS
On initial visit, both visual acuity was 0.3. Upon consider changing to fundoscopic examination, the patient was diagnosed with bilateral CRVO. We performed hematologic tests including thrombophilia examination. There were no abnormal findings on routine hematologic tests. Antinuclear antibody and rheumatoid factor were negative but anticardiolipin antibodies presented high titer, on two occasions six weeks apart. We prescribed oral aspirin and performed intravitreal bevacizumab injection under the diagnosis of bilateral CRVO in primary antiphospholipid syndrome.
CONCLUSIONS
It may be necessary to check antiphospolipid antibody in cases of bilateral CRVO in young patients without medical problem.

Keyword

Antiphospholipid syndrome; Anticardiolipin antibody; Central retinal vein occlusion

MeSH Terms

Adult
Antibodies, Anticardiolipin
Antibodies, Antinuclear
Antiphospholipid Syndrome*
Aspirin
Diagnosis
Hematologic Tests
Humans
Male
Ophthalmology
Retinal Vein*
Rheumatoid Factor
Thrombophilia
Visual Acuity
Bevacizumab
Antibodies, Anticardiolipin
Antibodies, Antinuclear
Aspirin
Rheumatoid Factor

Figure

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  Figure 1. Fundus photographs show multiple retinal hemorrhages, macular edema, and dilated tortuous vessels.

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  Figure 2. OCT scans show serous macular detachment in both eyes.

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  Figure 3. Fundus photographs show diminution of retinal hemorrhage and macular edema at 9 months after intravitreal bevacizumab injection.

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  Figure 4. OCT scans show nearly normal foveal contour and thickness at 9 months after intravitreal bevacizumab injection in both eyes.

Reference

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