J Korean Ophthalmol Soc.  2006 Dec;47(12):1901-1910.

Clinical Effects of Various Antiinflammatory Therapies in Dry Eye Syndrome

• Her J
• Yu SI
• Seo SG

Abstract

PURPOSE: To evaluate the therapeutic effect of cyclosporin A, corticosteroid, autologous serum in patients with severe dry eye syndrome.
METHODS
Patients (72 eyes) with severe dry eye syndrome were classified into four groups were treated for 3 months. Each group was treated with 0.05% cyclosporin A, 1% rimexolone, 20% autologous serum, and artificial tears. Before and after treatment (2, 4, 8, 12 weeks), Ocular Surface Disease Index (OSDI), tear film break-up time (BUT), Schirmer test, corneal sensitivity, and lissamine green staining score were measured.
RESULTS
After treatment, OSDI, tear film BUT, Schirmer test, corneal sensitivity, and the lissamine green staining score were improved in groups using cyclosporin A, autologous serum and corticosteroid(p<0.05), but clinical effects did not improve in the group using artificial tears except for corneal sensitivity (p>0.05).
CONCLUSIONS
Antiinflammatory theraphy is more effective than the conventional symptomatic theraphy in patients with severe dry eye syndrome.

Keyword

Antiinflammatory theraphy; Autologous serum; Corticosteroid; Cyclosporin A; Dry eye syndrome

MeSH Terms

Cyclosporine
Dry Eye Syndromes*
Humans
Ophthalmic Solutions
Tears
Cyclosporine
Ophthalmic Solutions