J Korean Pediatr Soc.  1978 May;21(5):389-395.

Clinical Studies on Neonatal Hepatitis

• Lee HK
• Lee MH
• Han DG
• Yun DJ

Abstract

43 cases of neonatal hepatitis were clinicallt evaluated, who were admitted to the pediatric department of Severance hospital furing period from April, 1956 to Februart, 1976. The following results were obtained. There was little difference in sex incidence, and most of them were admitted at the age of 1 month to 3 months after birth. Clinical symptoms and signs on admission were jaundice(95%), hepatomegaly(95%), splenom-egaly(41%), fever(41%), and cough(20%). Clay-colored stool was found in 34 cases(79%), and jaundice was found within 6 weeks after birth in most patients. In laboratory studies, total bilirubin, SGOT, SGPT, and Al. phosphatase were all elevated, and return to normal level at 5 weeks after admission. For the precise diagnosis, needle biopsy of the liver was done in 18 cases, among which 14cases showed multinucleated giant cells in specimen, but in 4 cases, giant cells were not observed, and only intrabepatic cholestasis was seen. As complication, bronchopneumonia(9 cases), sepsis(6 cases), rickets(3 cases), and bleeding(4 cases) developed, but which did not influence the prognosis. Most patients were recovered completely, but 6 patients died during admission and 7 patients were discharged in a hopeless condition.

MeSH Terms

Alanine Transaminase
Aspartate Aminotransferases
Bilirubin
Biopsy, Needle
Cholestasis
Diagnosis
Giant Cells
Hepatitis*
Humans
Incidence
Jaundice
Liver
Parturition
Prognosis
Alanine Transaminase
Aspartate Aminotransferases
Bilirubin