J Korean Ophthalmol Soc.  2006 Feb;47(2):181-185.

Efficacy of Silicone Nasolacrimal Intubation with Mitomycin C Treatmentfor Treatment of Incomplete Nasolacrimal Duct Obstruction

• Kim DS
• Lee YJ

Abstract

PURPOSE: To investigate the efficacy and safety of adjunctive Mitomycin C (MMC) during silicone intubation (SI) for treatment of acquired incomplete nasolacrimal duct obstruction (NLDO).
METHODS
Nineteen eyes with incomplete NLDO underwent SI only (group I). 20 different eyes were administered adjunctive 0.4 mg/ml MMC for 4 minutes (group II). Diagnosis of incomplete NLDO was based upon subjective complaints of tearing, dye disappearance testing, clinical evidence of epiphora, and nasolacrimal duct irrigation. Follow-up examination was conducted at 1, 3, and 6 months.
RESULTS
Follow-up ranged from 3 to 15 months (mean, 6.1 months). Twelve (63.1%) eyes in group I and 14 (70.0%) eyes in group II had a successful outcome and remained symptom-free. Four (21.1%) eyes in group I and three (15.0%) eyes in group II showed improvement but still experienced periodic epiphora. The difference was not statistically significant (p=0.873).
CONCLUSIONS
SI as a treatment for incomplete NLDO provides complete relief or substantial improvement in a significant percentage of patients but MMC application during SI did not benefit outcome.

Keyword

Mitomycin C; Nasolacrimal duct obstruction; Silicone intubation

MeSH Terms

Diagnosis
Follow-Up Studies
Humans
Intubation*
Lacrimal Apparatus Diseases
Mitomycin*
Nasolacrimal Duct*
Silicones*
Mitomycin
Silicones