J Korean Ophthalmol Soc.  2003 Dec;44(12):2885-2889.

The Effect of Nerve Growth Factor on Corneal Sensitivity after Laser in Situ Keratomileusis

• Jo SH
• Joo MJ
• O'Brien TP

Abstract

PURPOSE
To determine if topically administered nerve growth factor (NGF) plays a role in accelerating the recovery of corneal sensitivity after laser in situ keratomileusis (LASIK). METHODS: A prospective double-masked study comparing the effect of topical NGF or balanced salt solution on corneal sensitivity after LASIK in rabbits was performed. Pre- and postoperative corneal sensitivity was assessed using the Cochet-Bonnet esthesiometer. RESULTS: Eyes that were treated with topical NGF demonstrated an earlier and faster recovery of corneal sensitivity after LASIK (p=0.0071). A statistically significant difference in corneal sensitivity was found between the topical NGF and control group at the postoperative time points of 2 weeks (p=0.0098), 3 weeks (p=0.0309), and 4 weeks (p=0.0276). CONCLUSIONS: Our results suggest that topically administered NGF plays a significant role in accelerating corneal reinnervation after LASIK.

Keyword

Corneal sensitivity; LASIK; Nerve growth factor

MeSH Terms

Double-Blind Method
Keratomileusis, Laser In Situ*
Nerve Growth Factor*
Prospective Studies
Rabbits
Nerve Growth Factor