J Korean Ophthalmol Soc.
2002 Jul;43(7):1310-1322.
Study on Fibrovascular Ingrowth into the Intraocular Implant, Medpor(R)
- Affiliations
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- 1Department of Ophthalmology, Busan Paik Hospital, The Inje University Medical College, Korea. seossg@hanmail.net
- 2Shin & Park eye clinic, Korea.
- 3Department of Ophthalmology, College of medicine, Busan national University, Korea.
Abstract
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PURPOSE: We investigated the effects of bFGF/Sucralfate/Hydron suspension and hyperbaric oxygen on fibrovascular ingrowth into porous implants materials.
METHODS
Eight rabbits underwent bilateral abdominal incision through which porous orbital disc-shaped implants were inserted between abdominal muscles. These implants were either uncoated or coated with suspension of bFGF/Sucralfate/Hydron. Hyperbaric oxygen therapy was performed on 4 selected rabbits for 5 days or 10 days. Implants were harvested after 3 days, 1 week, 2 weeks and 4 weeks.
RESULTS
Enhanced fibrovascular ingrowth was shown in bFGF/Sucralfate/Hydron or hyperbaric oxygen treated implants. bFGF/Sucralfate/Hydron treated implants demonstrated more fibrovascularization than hyperbaric oxygen treated implants.
CONCLUSIONS
Simultaneous therapy of bFGF/Sucralfate/Hydron and hyperbaric oxygen showed more fibrovascularization than separately treated implants.
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