J Korean Ophthalmol Soc.  2001 Jul;42(7):1102-1110.

The Effect of Topical Mitomycin C after Excisional Biopsy in Conjunctival-corneal Intraepithelial Neoplasia: Two cases

• Kim JH
• Kang HS
• Kim IC

Abstract

PURPOSE
To investigate the effect of topical Mitomycin C(MMC) as a medical adjunct to incompletely excised conjunctival-corneal intraepithelial neoplasia(CCIN) for removal of remaining neoplastic cells and prevention of recurrence.
METHODS
The authors applied postoperative topical 0.02% MMC adjunctively on 2 eyes of 2 patients with incompletely excised and histopathologically confirmed conjunctival-corneal intraepithelial neoplasia(CCIN) for 2weeks and if the lesion is not regressed, topical MMC treatment with the same regimen was added.
RESULTS
Remaining lesions were completely regressed and no recurrence has been found with follow up to 25 months and 26 months in each case.
CONCLUSIONS
Topical MMC chemotherapy would be an effective treatment modality on incompletely excised conjunctival-corneal intraepithelial neoplasia(CCIN) for removal of remaining neoplatic cells and prevention of recurrence.

Keyword

Conjunctival-corneal intraepithelial neoplasia(CCIN); Incomplete Excision; Topical mitomycin C

MeSH Terms

Biopsy*
Drug Therapy
Follow-Up Studies
Humans
Mitomycin*
Recurrence
Mitomycin