J Korean Ophthalmol Soc.  2001 Mar;42(3):507-511.

The Effect of Aqueous Humor Suppressants on the Duration of Intravitreal Perfluorocarbon Gas Bubble in Rabbits

• Ryu GW
• Kim YI
• Yun IH

Abstract

PURPOSE: Although the process by which intravitreal perfluorocarbon gas is absorbed is incompletely understood, it is known that considerable absorption of intravitreal perfluorocarbon gas occurs through the aqueous humor. The aim of the study was to evaluate experimentally the effect of topical aqueous humor suppressants on the intravitreal perfluorocarbon gas bubble duration.
METHODS
After sulfur hexafluoride and perfluoropropane were injected intravitreally in ten rabbits, we measured the time of gas bubble disappearance in eyes treated with topical aqueous humor suppressants and in those not treated.
RESULTS
The mean time(+/-SD) to disappearance of 0.4 cc of sulfur hexafluoride was 6.0+/-0.71 days, which was prolonged to 8.0+/-0.71 days with topical aqueous humor suppressants. The mean time(+/-SD) to disappearance of 0.2 cc perfluoropropane was 14.8+/-0.84 days, while it was prolonged to 22.0+/-1.58 days with topical aqueous humor suppressants.
CONCLUSIONS
Sulfur hexafluoride and perfluoropropane intravitreal gas bubbles last longer in rabbit eyes treated with aqueous humor suppressants than in fellow control eyes.

Keyword

Aqueous humor supprassants; Intravitreal perfluorocarbon gas duration

MeSH Terms

Absorption
Aqueous Humor*
Rabbits*
Sulfur Hexafluoride
Sulfur Hexafluoride