J Korean Ophthalmol Soc.  2000 Feb;41(2):459-468.

Comparison of the Intraocular Pressure Reducing E ffect of Latanoprost with Timolol

• Lee H
• Kim CY
• Kim HK
• Hong YJ

Abstract

We compared the intraocular pressure reducing effect and side effects of 0.005%Latanoprost administered once daily with 0.5%Timolol administered twice daily in patients with open-angle glaucoma or ocular hypertension. This was an open randomized study with two parallel groups and a treatment period of 12 weeks. A total of 76 patients were included:38 in the Latanoprost group and 38 in the Timolol group. Intraocular pressure was reduced from 25.92 mms of mercury to 17.12 mms of mercury[33.91%]with Latanoprost and from 22.53 mms of mercury to 18.38 mms of mercury[18.42%]with Timolol. The efficacy of Latanoprost was statistically superior to timolol[p<0.001]. Latanoprost induced a slight conjunctival hyperemia and ocular discomfort but both drugs were generally well tolerated. Iris hyperpigmentation reported as a significant side effect of Latanoprost was not observed during 12 weeks of follow-up. It is concluded that Latanoprost administered once daily in the evening reduced intraocular pressure as well as and probably more than Timolol administered twice daily.

Keyword

Glaucoma; Intraocular pressure; Latanoprost; Timolol

MeSH Terms

Follow-Up Studies
Glaucoma
Glaucoma, Open-Angle
Humans
Hyperemia
Hyperpigmentation
Intraocular Pressure*
Iris
Ocular Hypertension
Timolol*
Timolol