J Korean Ophthalmol Soc.  1997 Sep;38(9):1641-1646.

Surgical Outcome of Intraoperative Episcleral Application of 5-Fluorouracil in Primary Trabeculectomy

• Yang JG
• Kee C

Abstract

We analyzed the outcome of primary trabeculectomy performed with intraoperative 5-fluorouracil(5-FU) sponge application on episclera and under lamella scleral flap in seventeen uncomplicated glaucoma eyes. The mean preoperative intraocular pressure(IOP) was 36.8+/-11.0mmHg. The mean postoperative IOP was 14.2+/-3.5mmHg after mean follow-up of 11.4 months. Two eyes required additional anti-glaucoma medications. Compliations included chronic hypotony(1 eye), shallow anterior chamber(2 eyes), and hyphema (1 eye). No eye showed corneal problems, hypotonic maculopathy, and bleb leakage. This study suggests that a single intraoperative use of 5-FU in primary trabeculectomy is an effective way of improving IOP control and of decreasing complications in eyes with uncomplicated glaucoma.

Keyword

5-fluorouracil; trabeculectomy; uncomplicated glaucoma

MeSH Terms

Blister
Fluorouracil*
Follow-Up Studies
Glaucoma
Hyphema
Porifera
Trabeculectomy*
Fluorouracil