J Korean Ophthalmol Soc.
1995 Dec;36(12):2213-2217.
Efficacy of High Dose Corticosteroid Therapy in Experimental Traumatic Optic Neuropathy
- Affiliations
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- 1Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea.
- 2Department of Pathlogy, College of Medicine, Yonsei University, Seoul, Korea.
Abstract
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We investigated the efficacy of high dose corticosteroid therapy in the treatment of traumatic optic-neuropathy. We experimentally damaged the optic nerves of six white rabbits with a Hartman mosquito. Three of the rabbits were intravenously injected with 0.25mg/kg dexamethasone every six hours for a 48 hour period. The others were used as controls. In both groups, the optic nerves were removed after one month and stained with Hematoxyline-eosin, then examined microscopically. No histological differences were found in either the control or the experimental group.