J Korean Rheum Assoc.
2000 Jun;7(2):168-173.
A Case of Churg-Strauss Syndrome with Nephrotic Range Proteinuria
- Affiliations
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- 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Abstract
- Churg-Strauss syndrome or allergic granulomatosis and angiitis is a part of spectrum of systemic vasculitis characterized by asthma, eosinophilia, mono or polyneuropathy, nonfixed pulmonary infiltrates, paranasal sinus abnormality and extravascular eosinophil infiltration. We experienced a case of Churg-Strauss syndrome of 21-year-old male patient with purpura and pitting edema on both hands and feet. He also had heavy proteinuria of nephrotic range and renal failure. Renal biopsy demonstrated crescentic glomerulonephritis with massive infiltration of eosinophils, lymphocytes and plasma cells in the interstitium. Under the treatment with prednisolone and cyclophosphamide, serum creatinine level and amount of proteinuria were reduced.
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