J Korean Rheum Assoc.  2002 Dec;9(4):249-255.

Increased Serum Concentration of Monocyte Chemoattractant Protein-1 in Systemic Lupus Erythematosus Patients with Antiphospholipid Syndrome

• Park JS
• Park KS
• Choi JJ
• Yoon JH
• Kim YJ
• Kim WU
• Min DJ
• Park SH
• Cho CS
• Kim HY

Abstract

OBJECTIVE
To determine the association of serum monocyte chemoattractant protein-1 (MCP-1) concentration and clinical variables of antiphospholipid syndrome (APS).
METHODS
We investigated the serum concentration of MCP-1 in systemic lupus erythematosus (SLE) patients by ELISA. The clinical features of APS were evaluated in SLE patients, and anticardiolipin antibody (aCL) was determined at the time of blood sampling.
RESULTS
Serum MCP-1 levels (median [range]) in 76 SLE patients were significantly higher than those in 99 healthy controls (192 pg/ml [116, 560] versus 91 pg/ml [26~251], p<0.001). Patients with APS had higher levels of serum MCP-1 than those without (p=0.013). Seum MCP-1 levels were significantly higher in patients with thrombosis and recurrent fetal loss than those without. Among APS patients, patients with longer disease duration (>3 years) had higher levels of MCP-1 than those without (263 pg/ml [166,534] versus 196 pg/ml [116,322], P=0.023). Furthermore, serum MCP-1 levels correlated well with IgG aCL titers (r=0.62, p<0.001).
CONCLUSION
Serum MCP-1 levels were elevated in SLE patients, particularly in those with APS, and correlated well with titers of IgG aCL and thrombosis. Our data suggest that increased MCP-1 may play a critical role in the development of APS in SLE patients.

Keyword

Monocyte chemoattractant protein-1; Thrombosis; Antiphospholipid syndrome; Systemic lupus erythematosus

MeSH Terms

Antibodies, Anticardiolipin
Antiphospholipid Syndrome*
Chemokine CCL2*
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin G
Lupus Erythematosus, Systemic*
Monocytes*
Thrombosis
Antibodies, Anticardiolipin
Chemokine CCL2
Immunoglobulin G