J Korean Rheum Assoc.  2007 Mar;14(1):43-50. 10.4078/jkra.2007.14.1.43.

Extraglandular Manifestations and Autoantibodies of Korean Patients with Primary Sjogren's Syndrome

• Seo SH
• Kim HS
• Kwok SK
• Ju JH
• Kim SH
• Yoon CH
• Kim HY
• Park SH

• KMID: 2202189
• DOI: http://doi.org/10.4078/jkra.2007.14.1.43

Abstract

OBJECTIVE
To investigate the extraglandular manifestations and serological features of Korean patients with primary Sjogren's syndrome (pSS).
METHODS
Clinical and laboratory data of 125 patients with pSS attending rheumatology clinic of Kangnam St. Mary's hospital, with a mean follow-up period of 64.8 months, were assessed retrospectively.
RESULTS
Arthralgia was the most common extraglandular manifestation of pSS. Other extraglandular manifestations, such as myalgia, peripheral neuropathy, Raynaud's phenomenon, and hypothyroidism were frequently presented, but lymphoma was rare manifestation in Korean patients with pSS. Some extraglandular manifestations of pSS were associated with hypocomplementemia and antibodies against Ro, and La, and antinuclear antibody.
CONCLUSION
The clinical manifestations and extraglandular manifestations of Korean patients with pSS patients were similar to other studies except low prevalence of lymphoma. Positivity of anti-Ro/SS-A, anti-La/SS-B antibodies and hypocomplementemia were closely associated with extraglandular manifestations in patients with pSS.

Keyword

Primary Sjogren's syndrome; Extraglandular manifestation; Autoantibody; Hypocomplementemia

MeSH Terms

Antibodies
Antibodies, Antinuclear
Arthralgia
Autoantibodies*
Follow-Up Studies
Humans
Hypothyroidism
Lymphoma
Myalgia
Peripheral Nervous System Diseases
Prevalence
Retrospective Studies
Rheumatology
Sjogren's Syndrome*
Antibodies
Antibodies, Antinuclear
Autoantibodies

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