J Korean Rheum Assoc.  2009 Jun;16(2):71-73. 10.4078/jkra.2009.16.2.71.

The Efficacy and Safety of Leflunomide in the Treatment of Rheumatoid Arthritis

• Choe JY

• KMID: 2202121
• DOI: http://doi.org/10.4078/jkra.2009.16.2.71

Abstract

No abstract available.

MeSH Terms

Arthritis, Rheumatoid
Isoxazoles
Isoxazoles

Reference

References

1. American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines. Guidelines for the management of rheumatoid arthritis: 2002 Update. Arthritis Rheum. 2002; 46:328–46.

2. Park YB, Lee SK. Leflunomide; a new disease modifying antirheumatic drug. J Korean Rheum Assoc. 2000; 7:323–32.

3. Saag KG, Teng GG, Patkar NM, anuntiyo J, Finney C, Curtis JR, et al. American College of Rheumatology 2008 Recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis. Arthritis Rheum. 2008; 59:762–84.

4. Chang JH, Jung ES, Lee JH, Yoon BY, Lee CH, Lee YW. Hepatotoxicity of combination treatment with leflunomide and methotrexate in RA patients. J Korean Rheum Assoc. 2009; 16:16–22.

5. Chung SH, Kim HJ, Kim SH, Kim CG, Hwang IS, Choe JY. Combination treatment with leflunomide and methotrexate in patients with rheumatoid arthritis: the efficacy, safety, and predisposing factors for treatment response. Korean J Med. 2005; 69:10–20.

6. Ju JH, Kim SI, Lee JH, Lee SI, Yoo WH, Choe JY, et al. Risk of interstitial lung disease associated with leflunomide treatment in Korean patients with rheumatoid arthritis. Arthritis Rheum. 2007; 56:2094–6.

7. Lee SS, Park YW, Park JJ, Kang YM, Nam EJ, Kim SI, et al. Combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis. Scand J Rheumatol. 2009; 38:11–4.

8. Strand V, Cohen S, Schiff M, Weaver A, Fleischmann R, Cannon G, et al. Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Arch Intern Med. 1999; 159:2542–50.

9. Kremer JM, Genovese MC, Cannon GW, Caldwell JR, Cush JJ, Furst DE, et al. Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. Ann Intern Med. 2002; 137:726–33.

10. Curtis JR, Beukelman T, Onofrei A, Cassell S, Greenberg JD, Kavanaugh A, et al. Elevated liver enzyme tests among rheumatoid arthritis and psoriatic arthritis patients treated with methotrexate and/or leflunomide. Ann Rheum Dis 2009 Jan 15 [Epub ahead of print].