J Korean Rheum Assoc.  2008 Sep;15(3):273-276. 10.4078/jkra.2008.15.3.273.

A Case of Peripheral Neuropathy in a Patient with Rheumatoid Arthritis Treated with Leflunomide

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea.
  • 2The Hospital for Rheumatic Diseases, College of Medicine, Hanyang University, Seoul, Korea. junjb@hanyang.ac.kr
  • 3Department of Neurology3, College of Medicine, Hanyang University, Seoul, Korea.

Abstract

Leflunomide is a new disease-modifying drug licensed for treatment of rheumatoid arthritis. Recently, neuropathy has been reported with leflunomide. We report a case of peripheral neuropathy in rheumatoid arthritis treated with leflunomide. Nerve conduction study and electromyogram show sensory-motor polyneuropathy of both upper and lower limbs. Leflunomide medication was discontinued and cholestryamine washout was performed with some improvement in a couple of weeks.

Keyword

Leflunomide; Neuropathy; Arthritis Rheumatoid
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