J Korean Pediatr Cardiol Soc.  2006 Dec;10(4):462-467.

Significances of Echocardiography Using Tissue Doppler Imaging for Children in Growth Hormone Therapy

• Lee HS
• Chung WC
• Jeong YS
• Jung JW

Abstract

PURPOSE: The purpose of this study is to evaluate the functional changes of the ventricles for 27 children with recombinant human growth hormone (rhGH) therapy in short stature using echocardiography with tissue Doppler imaging.
METHODS
The conventional Doppler echocardiography with tissue Doppler imaging were performed in 27 children with rhGH therapy for short stature and 13 healthy children. Peak velocities of systolic (S) and early (E'), late(A') diastolic wave of mitral annulus,septum and tricuspid annulus were obtained from apical 4 chamber view.
RESULTS
There was no differences in left ventricle (LV) mass (72.948+/-11.825 m/s2 vs 73.931+/-12.093 m/s2, P=0.08), LV ejection fraction (66.778+/-5.441% vs 70.154+/-6.641%, P=0.095) and LV fractional shortening (36.737+/-4.265% vs 38.085+/-3.419, P=0.327) were observed between patients and controls. There was no significant differences in E and A measured at mitral and tricuspid annulus were observed between pateints and controls. There was no significant differences in S, E' and A' measured using tissue doppler imaging at mitral annulus, septum, and tricuspid annulus were observed between patients and controls
CONCLUSION
No significant differences in parameters of cardiac function using tissue doppler imaging with conventional echocardiography were found between patients with rhGH therapy and controls. But, longer follow-up, involving at a larger number of patients, is required to confirm the safety of long-term rhGH treatment.

Keyword

Growth hormone therapy; Echocardiography; Tissue Doppler imaging; Left ventricular function

MeSH Terms

Child*
Echocardiography*
Echocardiography, Doppler
Follow-Up Studies
Growth Hormone*
Heart Ventricles
Human Growth Hormone
Humans
Ventricular Function, Left
Growth Hormone
Human Growth Hormone