J Korean Pediatr Cardiol Soc.  2007 Sep;11(3):229-234.

Association between Coronary Artery Abnormality and Serum Amyloid A in Kawasaki Disease

• Suh JS
• Jee HY
• Kwon O
• Lee HY

Abstract

PURPOSE: Kawasaki disease can cause cardiovascular complications if not properly treated from the beginning. Recently, serum amyloid A(SAA) was reported to be a predictive factor of cardiovascular diseases. Therefore, it was examined whether the existence of coronary artery abnormality in Kawasaki disease can be predicted in acute stage.
METHODS
Forty nine patients who were diagnosed with Kawasaki disease between October, 2006 and May, 2007 at Yonsei University, Wonju College of Medicine were selected for this study. We reviewed results of CBC, AST, ALT, CK, LDH, total bilirubin, albumin, CRP, CK-MB, troponin-I, LDL, HDL, SAA, ESR. We divided the patients into two groups: Group A consisting of patients with coronary artery lesions, and group B consisting of patients without coronary artery lesions.
RESULTS
CRP was significantly higher in group A (group A 11.0+/-7.0 mg/dL vs group B 5.3+/-5.3 mg/dL, P=0.030). SAA was slightly higher in group A but did not show any statistical significance (group A 283.8+/-357.3 microgram/mL vs group B 133.2+/-293.4 microgram/mL, P=0.128). Binary regression analysis was used to identify the significance of SAA as a predictor of coronary artery abnormality but did not find any significance (SAA OR=1.000, 95% CI=0.998-1.002, P=0.950).
CONCLUSION
SAA are not significant predictors of coronary artery abnormality in Kawasaki disease but are non specific factors which increase in the acute stage.

Keyword

Kawasaki disease; Serum amyloid A; Coronary artery abnormality

MeSH Terms

Amyloid
Bilirubin
Cardiovascular Diseases
Coronary Vessels*
Gangwon-do
Humans
Mucocutaneous Lymph Node Syndrome*
Serum Amyloid A Protein*
Troponin I
Amyloid
Bilirubin
Serum Amyloid A Protein
Troponin I