J Menopausal Med.  2015 Aug;21(2):82-88. 10.6118/jmm.2015.21.2.82.

Factors Associated with Mammographic Density in Postmenopausal Women

  • 1Department of Obstetrics and Gynecology, Faculty of Medicine, Bozok University, Yozgat, Turkey. emelkiyak@hotmail.com
  • 2Department of Surgery, Faculty of Medicine, Bozok University, Yozgat, Turkey.
  • 3Department of Obstetrics and Gynecology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
  • 4Department of Radiology, Faculty of Medicine, Bozok University, Yozgat, Turkey.


Breast density increases the risk of breast cancer, but also in the interpretation of mammography is also important. This study examine the risk factors affecting breast density in postmenopausal women.
Between January 2013 and January 2014, 215 patients admitted to The Clinics of Gynecology and Obstetrics with complaints of menopause were taken. According to the results of mammography, Group I (non-dense, n = 175) and Group II (dense, n = 40) were created. The informations of the caseswere analyzed retrospectively.
In Group I, body mass index (BMI), number of pregnancies, parity were significantly higher than group II (P < 0.05). In group II, the withdrawal period of menstruation and progesterone levels were significantly higher (P < 0.05). In logistic regression analysis, BMI for dense breasts and number of pregnancies were found to be an independent risk factor (P < 0.05).
Increased BMI, pregnancy and parity, result of reduction in density , but longer duration of menopause and increased progesterone cause an increase in density. BMI and the number of pregnancy was found to be independent risk factors for reducing breast density.


Mammary glands human; Mammography; Postmenopause

MeSH Terms

Body Mass Index
Breast Neoplasms
Logistic Models
Retrospective Studies
Risk Factors

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1. Lundström E, Wilczek B, von Palffy Z, Söderqvist G, von Schoultz B. Mammographic breast density during hormone replacement therapy: differences according to treatment. Am J Obstet Gynecol. 1999; 181:348–352.
2. Fasching PA, Heusinger K, Loehberg CR, Wenkel E, Lux MP, Schrauder M, et al. Influence of mammographic density on the diagnostic accuracy of tumor size assessment and association with breast cancer tumor characteristics. Eur J Radiol. 2006; 60:398–404.
3. Quintana C, Redondo M, Tirao G. Implementation of several mathematical algorithms to breast tissue density classification. Radiat Phys Chem. 2014; 95:261–263.
4. Jackson VP, San Martin JA, Secrest RJ, McNabb M, Carranza-Lira S, Figueroa-Casas P, et al. Comparison of the effect of raloxifene and continuous-combined hormone therapy on mammographic breast density and breast tenderness in postmenopausal women. Am J Obstet Gynecol. 2003; 188:389–394.
5. Brand JS, Czene K, Eriksson L, Trinh T, Bhoo-Pathy N, Hall P, et al. Influence of lifestyle factors on mammographic density in postmenopausal women. PLoS One. 2013; 8:e81876.
6. Ellison-Loschmann L, McKenzie F, Highnam R, Cave A, Walker J, Jeffreys M. Age and ethnic differences in volumetric breast density in new zealand women: a cross-sectional study. PLoS One. 2013; 8:e70217.
7. Fuhrman BJ, Brinton LA, Pfeiffer RM, Xu X, Veenstra TD, Teter BE, et al. Estrogen metabolism and mammographic density in postmenopausal women: a cross-sectional study. Cancer Epidemiol Biomarkers Prev. 2012; 21:1582–1591.
8. Kotsuma Y, Tamaki Y, Nishimura T, Tsubai M, Ueda S, Shimazu K, et al. Quantitative assessment of mammographic density and breast cancer risk for Japanese women. Breast. 2008; 17:27–35.
9. Sung J, Song YM, Stone J, Lee K. The relationship between bone mineral density and mammographic density in Korean women: the Healthy Twin study. Breast Cancer Res Treat. 2011; 129:583–591.
10. Seo JM, Ko ES, Han BK, Ko EY, Shin JH, Hahn SY. Automated volumetric breast density estimation: a comparison with visual assessment. Clin Radiol. 2013; 68:690–695.
11. D'Orsi CJ, Bassett LW, Berg WA, Feig SA, Jackson VP, Kopans DB. Breast imaging reporting and data system: ACR BI-RADS-mammography. 4th ed. Reston, VA: American College of Radiology;2003.
12. Ishihara S, Taira N, Kawasaki K, Ishibe Y, Mizoo T, Nishiyama K, et al. Association between mammographic breast density and lifestyle in Japanese women. Acta Med Okayama. 2013; 67:145–151.
13. Martin LJ, Minkin S, Boyd NF. Hormone therapy, mammographic density, and breast cancer risk. Maturitas. 2009; 64:20–26.
14. Warren R. Hormones and mammographic breast density. Maturitas. 2004; 49:67–78.
15. Boyd NF, Rommens JM, Vogt K, Lee V, Hopper JL, Yaffe MJ, et al. Mammographic breast density as an intermediate phenotype for breast cancer. Lancet Oncol. 2005; 6:798–808.
16. Warwick J, Pinney E, Warren RM, Duffy SW, Howell A, Wilson M, et al. Breast density and breast cancer risk factors in a high-risk population. Breast. 2003; 12:10–16.
17. Tsvetov G, Levy S, Benbassat C, Shraga-Slutzky I, Hirsch D. Influence of number of deliveries and total breast-feeding time on bone mineral density in premenopausal and young postmenopausal women. Maturitas. 2014; 77:249–254.
18. Rice MS, Bertrand KA, Lajous M, Tamimi RM, Torres-Mejia G, Biessy C, et al. Body size throughout the life course and mammographic density in Mexican women. Breast Cancer Res Treat. 2013; 138:601–610.
19. Ooms EA, Zonderland HM, Eijkemans MJ, Kriege M, Mahdavian Delavary B, Burger CW, et al. Mammography: interobserver variability in breast density assessment. Breast. 2007; 16:568–576.
20. Tamburrini AL, Woolcott CG, Boyd NF, Yaffe MJ, Terry T, Yasui Y, et al. Associations between mammographic density and serum and dietary cholesterol. Breast Cancer Res Treat. 2011; 125:181–189.
21. Tehranifar P, Reynolds D, Fan X, Boden-Albala B, Engmann NJ, Flom JD, et al. Multiple metabolic risk factors and mammographic breast density. Ann Epidemiol. 2014; 24:479–483.
22. Marchesoni D, Driul L, Ianni A, Fabiani G, Della Martina M, Zuiani C, et al. Postmenopausal hormone therapy and mammographic breast density. Maturitas. 2006; 53:59–64.
23. von Schoultz B. The effects of tibolone and oestrogen-based HT on breast cell proliferation and mammographic density. Maturitas. 2004; 49:S16–S21.
24. Kiran H, Tok A, Yuksel M, Arikan DC, Ekerbicer HC. Estradiol plus drospirenone therapy increases mammographic breast density in perimenopausal women. Eur J Obstet Gynecol Reprod Biol. 2011; 159:384–387.
25. Colacurci N, Fornaro F, De Franciscis P, Palermo M, del Vecchio W. Effects of different types of hormone replacement therapy on mammographic density. Maturitas. 2001; 40:159–164.
26. Christodoulakos GE, Lambrinoudaki IV, Vourtsi AD, Vlachou S, Creatsa M, Panoulis KP, et al. The effect of low dose hormone therapy on mammographic breast density. Maturitas. 2006; 54:78–85.
27. Junkermann H, von Holst T, Lang E, Rakov V. Influence of different HRT regimens on mammographic density. Maturitas. 2005; 50:105–110.
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