Korean J Obstet Gynecol.  2005 Feb;48(2):411-417.

Hormone replace therapy and changes in mammographic density in postmenopausal women

• Seo SB
• Jee KN
• Park JW

Abstract

OBJECTIVE
To evaluate the changes in mammographic density by different types of hormone replace therapy (HRT) in postmenopausal women.
METHODS
A total of 150 postmenopausal women who received same HRT regimen for 1 year were classified as the four groups according to the regimen of HRT; 1) daily conjugated equine estrogen (CEE) 0.625 mg+medroxiprogesterone acetate (MPA) 2.5 mg (CEE/MPA-continuous, n=42), 2) daily CEE 0.625 mg+MPA 10 mg on days 1-12 (CEE/MPA-cyclic, n=28), 3) daily CEE 0.625 mg (CEE only, n=40), 4) daily tibolone 2.5 mg (Tibolone, n=40). And 40 women were allocated as control group. The changes in mammographic density in each group were compared with before and after HRT for 1 year.
RESULTS
The increase in mammographic density after 1 year of HRT was significantly higher in CEE/MPA-continuous group and CEE/MPA-cyclic group compaired with control group (p<0.05), and was not observed in CEE only group and tibolone group.
CONCLUSION
Our results suggest that greater increase of mammographic density in postmenopausal women was significantly associated with estrogen/progestin combination therapy.

Keyword

Hormone replace therapy; Mammography; Breast density

MeSH Terms

Estrogens
Female
Humans
Mammography
Estrogens