J Menopausal Med.  2015 Dec;21(3):165-170. 10.6118/jmm.2015.21.3.165.

Uterine Lipoleiomyoma in Peri or Postmenopausal Women

• Oh SR
• Cho YJ
• Han M
• Bae JW
• Park JW
• Rha SH

• KMID: 2200971
• DOI: http://doi.org/10.6118/jmm.2015.21.3.165

Abstract

Lipoleiomyoma is an uncommon neoplasm of the uterus, composed of smooth muscles intermixed with mature adipocytes. These tumors are considered a benign variant of uterine leiomyomas. Herein, we report six cases of lipoleiomyoma experienced in our institution from January 2005 to March 2015. The patients ranged in age from 45 to 70 years; the etiology may be related to estrogen deficiency occurring after menopausal transition. Except for one lipoleiomyoma in the broad ligament, all others were found in the uterine corpus. The presenting symptoms were nonspecific, and most cases were incidentally diagnosed during surgery for other reasons. We performed preoperative imaging studies, including abdominal and pelvic computed tomography and magnetic resonance imaging. Preoperatively, four patients were diagnosed as having a pelvic mass and one patient was diagnosed as having a right ovarian mature teratoma. In one case, we found a gynecologic malignancy (cervical cancer 1A1). Histologically, there was no gross or microscopic contiguity between the lipoleiomyoma and the malignancy. Lipoleiomyomas seem to have a benign clinical course. In our study, there were no recurrences of or deaths attributed to the lipoleiomyomas during a mean follow-up period of 16.17 +/- 23.80 months.

Keyword

Leiomyoma; Myofibroma; Perimenopause; Postmenopause; Uterus

MeSH Terms

Adipocytes
Broad Ligament
Estrogens
Female
Follow-Up Studies
Humans
Leiomyoma
Magnetic Resonance Imaging
Muscle, Smooth
Myofibroma
Perimenopause
Postmenopause
Recurrence
Teratoma
Uterus
Estrogens

Figure

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  Fig. 1 Abdominal and pelvic computed tomography. Suspicious fat containing pelvic mass, maybe uterine origin.

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  Fig. 2 Pelvic magnetic resonance image. Fat containing heterogeneously enhancing mass, uterus body anterior wall subserosal layer.

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  Fig. 3 Admixture of smooth muscle and mature fat cells.

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  Fig. 4 Highly cellular leiomyoma was composed of interlacing bundles of spindle-shaped smooth muscle cells, no atypia and necrosis (H & E ×40).

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  Fig. 5 Mature fat cells (H & E ×100).

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