J Lung Cancer.  2002 Dec;1(1):9-14.

Surgery for Locally Advanced Non-Small Cell Lung Cancer

• Kim YT

Abstract

Surgical resection of locally advanced lung cancer is a challenging subject for thoracic surgeons. Although the operative mortality and morbidity have recently decreased, extended pulmonary resection still remains a high-risk procedure. In selective patients an extended resection would offer an increased chance of a cure from the disease. The most important prognostic factors for a locally advanced lung cancer are the mediastinal lymph node status and the completeness of the resection. Careful preoperative evaluations are required, and every effort to achieve a negative resection margin is of utmost importance during the operation. The recent development of neoadjuvant chemotherapy seems to be promising, but to draw any conclusion regarding the long-term survival benefits, multi-centered randomized trials are mandatory.

Keyword

NSCLC; Surgery

MeSH Terms

Carcinoma, Non-Small-Cell Lung*
Drug Therapy
Humans
Lung Neoplasms
Lymph Nodes
Mortality