J Lipid Atheroscler.  2012 Dec;1(2):69-78. 10.12997/jla.2012.1.2.69.

Effect of Adiponectin and Resistin on Coronary Plaque Composition and Coronary Artery Remodeling of Target Lesion in Patients with Stable Angina

• Kim JY
• Min PK
• Yoon YW
• Lee BK
• Hong BK
• Kwon HM

• KMID: 2198364
• DOI: http://doi.org/10.12997/jla.2012.1.2.69

Abstract

OBJECTIVE
The purpose of this study was to investigate the effect of adiponectin and resistin on coronary plaque composition determined by virtual histology (VH) intravascular ultrasound (IVUS) and coronary artery remodeling of target lesion in patients with stable angina.
METHODS
We prospectively enrolled 48 patients who underwent coronary angiography and VH IVUS for stable angina (27 men, 61+/-9 years of age). Preintervention grayscale and VH IVUS analysis was done across the target lesion. Planar VH IVUS analysis at the minimum luminal site and volumetric analysis over a 10-mm-long segment centered at the minimum luminal site were performed. The subjects were divided into 2 groups based on remodeling index (RI): positive remodeling (PR) defined as RI>1.0 and non-PR as RI< or =1.0. Blood samples for analysis of adiponectin and resistin were obtained from the femoral artery before coronary angioplasty.
RESULTS
Of the 48 patients enrolled, 23 (48%) had PR in their target lesion and 25 (52%) were non-PR group. Clinical and angiographic characteristics, VH IVUS parameters were not different between the PR and the non-PR groups. Adiponectin and resistin levels showed no significant correlations with coronary plaque composition evaluated with VH IVUS. Adiponectin showed no significant difference between the two groups. However, resistin showed trend toward higher level in non-PR group (4.17+/-2.18 ng/mL vs. 6.11+/-4.26 ng/mL, P=0.056) and a significant negative correlation with RI (r=-0.303, P=0.036).
CONCLUSION
We found a negative correlation between the resistin level and RI of a de-novo target lesion in patients with stable angina.

Keyword

Adiponectin; Resistin; Atherosclerotic plaque; Intravascular ultrasound; Arterial remodeling

MeSH Terms

Adiponectin
Angina, Stable
Coronary Angiography
Coronary Vessels
Femoral Artery
Humans
Male
Phenobarbital
Plaque, Atherosclerotic
Prospective Studies
Resistin
Adiponectin
Phenobarbital
Resistin

Figure

• 

  Fig. 1 Level of (A) adiponectin, (B) resistin, and (C) hs-CRP in the PR and Non-PR groups. The line within the box denotes the median, and the box spans the interquartile range (25th to 75th percentiles). The whiskers extend from the 10th to 90th percentiles. PR, positive remodeling; hs-CRP, high sensitivity C-reactive protein.

• 

  Fig. 2 Correlation between coronary artery remodeling index and (A) resistin (r=-0.303, P=0.036, y=-0.017x+1.068) or (B) hs-CRP (r=0.327, P=0.035, y=0.027x+0.942). hs-CRP, high sensitivity C-reactive protein.

• 

  Fig. 3 Correlation between target lesion plaque burden and adiponectin (r=-0.316, P=0.029, y=-0.001x+61.538).

Reference

1. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987; 316:1371–1375.

2. Hermiller JB, Tenaglia AN, Kisslo KB, Phillips HR, Bashore TM, Stack RS, Davidson CJ. In vivo validation of compensatory enlargement of atherosclerotic coronary arteries. Am J Cardiol. 1993; 71:665–668.

3. Losordo DW, Rosenfield K, Kaufman J, Pieczek A, Isner JM. Focal compensatory enlargement of human arteries in response to progressive atherosclerosis. In vivo documentation using intravascular ultrasound. Circulation. 1994; 89:2570–2577.

4. Pasterkamp G, Wensing PJ, Post MJ, Hillen B, Mali WP, Borst C. Paradoxical arterial wall shrinkage may contribute to luminal narrowing of human atherosclerotic femoral arteries. Circulation. 1995; 91:1444–1449.

5. Kimura T, Kaburagi S, Tamura T, Yokoi H, Nakagawa Y, Hamasaki N, Nosaka H, Nobuyoshi M, Mintz GS, Popma JJ, Leon MB. Remodeling of human coronary arteries undergoing coronary angioplasty or atherectomy. Circulation. 1997; 96:475–483.

6. Schoenhagen P, Ziada KM, Kapadia SR, Crowe TD, Nissen SE, Tuzcu EM. Extent and direction of arterial remodeling in stable versus unstable coronary syndromes: an intravascular ultrasound study. Circulation. 2000; 101:598–603.

7. Nair A, Kuban BD, Tuzcu EM, Schoenhagen P, Nissen SE, Vince DG. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation. 2002; 106:2200–2206.

8. Burnett MS, Lee CW, Kinnaird TD, Stabile E, Durrani S, Dullum MK, Devaney JM, Fishman C, Stamou S, Canos D, Zbinden S, Clavijo LC, Jang GJ, Andrews JA, Zhu J, Epstein SE. The potential role of resistin in atherogenesis. Atherosclerosis. 2005; 182:241–248.

9. Frankel DS, Vasan RS, D'Agostino RB Sr, Benjamin EJ, Levy D, Wang TJ, Meigs JB. Resistin, adiponectin, and risk of heart failure the Framingham offspring study. J Am Coll Cardiol. 2009; 53:754–762.

10. Yaturu S, Daberry RP, Rains J, Jain S. Resistin and adiponectin levels in subjects with coronary artery disease and type 2 diabetes. Cytokine. 2006; 34:219–223.

11. Marso SP, Mehta SK, Frutkin A, House JA, McCrary JR, Kulkarni KR. Low adiponectin levels are associated with atherogenic dyslipidemia and lipid-rich plaque in nondiabetic coronary arteries. Diabetes Care. 2008; 31:989–994.

12. Iwata A, Miura S, Mori K, Kawamura A, Nishikawa H, Saku K. Associations between metabolic factors and coronary plaque growth or arterial remodeling as assessed by intravascular ultrasound in patients with stable angina. Hypertens Res. 2008; 31:1879–1886.

13. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun. 1999; 257:79–83.

14. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol. 2000; 20:1595–1599.

15. Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, Hotta K, Nishida M, Takahashi M, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation. 1999; 100:2473–2476.

16. Kojima S, Funahashi T, Maruyoshi H, Honda O, Sugiyama S, Kawano H, Soejima H, Miyamoto S, Hokamaki J, Sakamoto T, Yoshimura M, Kitagawa A, Matsuzawa Y, Ogawa H. Levels of the adipocyte-derived plasma protein, adiponectin, have a close relationship with atheroma. Thromb Res. 2005; 115:483–490.

17. Nakamura Y, Shimada K, Fukuda D, Shimada Y, Ehara S, Hirose M, Kataoka T, Kamimori K, Shimodozono S, Kobayashi Y, Yoshiyama M, Takeuchi K, Yoshikawa J. Implications of plasma concentrations of adiponectin in patients with coronary artery disease. Heart. 2004; 90:528–533.

18. Otsuka F, Sugiyama S, Kojima S, Maruyoshi H, Funahashi T, Matsui K, Sakamoto T, Yoshimura M, Kimura K, Umemura S, Ogawa H. Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease. J Am Coll Cardiol. 2006; 48:1155–1162.

19. Broedl UC, Lebherz C, Lehrke M, Stark R, Greif M, Becker A, von Ziegler F, Tittus J, Reiser M, Becker C, Goke B, Parhofer KG, Leber AW. Low adiponectin levels are an independent predictor of mixed and non-calcified coronary atherosclerotic plaques. PLoS ONE. 2009; 4:e4733.

20. Otake H, Shite J, Shinke T, Watanabe S, Tanino Y, Ogasawara D, Sawada T, Hirata K, Yokoyama M. Relation between plasma adiponectin, high-sensitivity C-reactive protein, and coronary plaque components in patients with acute coronary syndrome. Am J Cardiol. 2008; 101:1–7.

21. On YK, Park HK, Hyon MS, Jeon ES. Serum resistin as a biological marker for coronary artery disease and restenosis in type 2 diabetic patients. Circ J. 2007; 71:868–873.

22. Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation. 2005; 111:932–939.

23. McManus DD, Lyass A, Ingelsson E, Massaro JM, Meigs JB, Aragam J, Benjamin EJ, Vasan RS. Relations of Circulating Resistin and Adiponectin and Cardiac Structure and Function: The Framingham Offspring Study. Obesity (Silver Spring). 2011.

24. Sabate M, Kay IP, de Feyter PJ, van Domburg RT, Deshpande NV, Ligthart JM, Gijzel AL, Wardeh AJ, Boersma E, Serruys PW. Remodeling of atherosclerotic coronary arteries varies in relation to location and composition of plaque. Am J Cardiol. 1999; 84:135–140.

25. Fuessl RT, Kranenberg E, Kiausch U, Baer FM, Sechtem U, Hopp HW. Vascular remodeling in atherosclerotic coronary arteries is affected by plaque composition. Coron Artery Dis. 2001; 12:91–97.

26. Varnava AM, Mills PG, Davies MJ. Relationship between coronary artery remodeling and plaque vulnerability. Circulation. 2002; 105:939–943.

27. Rodriguez-Granillo GA, Serruys PW, Garcia-Garcia HM, Aoki J, Valgimigli M, van Mieghem CA, McFadden E, de Jaegere PP, de Feyter P. Coronary artery remodelling is related to plaque composition. Heart. 2006; 92:388–391.

28. Takeuchi H, Morino Y, Matsukage T, Masuda N, Kawamura Y, Kasai S, Hashida T, Fujibayashi D, Tanabe T, Ikari Y. Impact of vascular remodeling on the coronary plaque compositions: an investigation with in vivo tissue characterization using integrated backscatter-intravascular ultrasound. Atherosclerosis. 2009; 202:476–482.

29. Fujii K, Carlier SG, Mintz GS, Wijns W, Colombo A, Bose D, Erbel R, de Ribamar Costa J Jr, Kimura M, Sano K, Costa RA, Lui J, Stone GW, Moses JW, Leon MB. Association of plaque characterization by intravascular ultrasound virtual histology and arterial remodeling. Am J Cardiol. 2005; 96:1476–1483.

30. Surmely JF, Nasu K, Fujita H, Terashima M, Matsubara T, Tsuchikane E, Ehara M, Kinoshita Y, Takeda Y, Tanaka N, Katoh O, Suzuki T. Association of coronary plaque composition and arterial remodelling: a virtual histology analysis by intravascular ultrasound. Heart. 2007; 93:928–932.

31. Nicholls SJ, Tuzcu EM, Kalidindi S, Wolski K, Moon KW, Sipahi I, Schoenhagen P, Nissen SE. Effect of diabetes on progression of coronary atherosclerosis and arterial remodeling: a pooled analysis of 5 intravascular ultrasound trials. J Am Coll Cardiol. 2008; 52:255–262.