J Korean Soc Pediatr Nephrol.
2010 Oct;14(2):166-173.
Influence of VEGF Genetic Polymorphism on Peritoneal Solute Transport in Pediatric Dialysis Patients
- Affiliations
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- 1Department of Preventive Medicine, College of Medicine, Seoul National University, Korea.
- 2Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.
- 3Division of Vaccine Preventable Disease Control and National Immunization Program, Korean Centers for Disease Control and Prevention, Korea.
- 4Department of Pediatrics, Seoul National University Children's Hospital, Korea. ilsooha@snu.ac.kr
- 5Department of Pediatrics, Inje University Haeundae Paik Hospital, Korea.
Abstract
- PURPOSE
Genetic and clinical factors can influence the permeability of the peritoneal membrane. The peritoneal equilibration test (PET) is helpful in measuring peritoneal permeability in peritoneal dialysis (PD). We investigated the influence of genetic polymorphism of vascular endothelial growth factor (VEGF) on the PET parameters.
METHODS
Pediatric patients who underwent PET within 12 months of initiating PD at Seoul National University Children's Hospital and Samsung Medical Center were selected. The patients with positive history of peritonitis before PET were excluded. The VEGF -2578C/A, -14978T/C, -1154G/A, -634G/C, and +936C/T single-nucleotide polymorphisms were genotyped.
RESULTS
The mean 4-hour dialysate-to-plasma ratio for creatinine (D/P creatinine) and the mean 4-hour dialysate glucose to baseline dialysate glucose ratio (D/D0 glucose) were 0.56+/-0.13 and 0.43+/-0.11, respectively. The patients with haplotype CTGGC showed higher 4-hour D/P creatinine (0.67+/-0.12 vs 0.50+/-0.09, P=0.007) and lower 4-hour D/D0 glucose (0.35+/-0.12 vs 0.47+/-0.08, P=0.037) than those without haplotype CTGGC.
CONCLUSION
The VEGF genetic polymorphism may influence the peritoneal solute transport.
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